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NLS Pharmaceutics Ltd.

2.30

+0.220010.58%

Post-market: 2.300.00000.00%19:59 EDT

Volume:577.63K

Turnover:1.28M

Market Cap:8.27M

PE:-0.35

High:2.30

Open:2.20

Low:2.10

Close:2.08

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Overview Company News Filings

NLS Pharmaceutics AG Announces Fourth Amendment to Merger Agreement with Kadimastem Ltd

NLS Pharmaceutics to present new preclinical data on Mazindol ER at ASCP

NLS Pharmaceutics AG Reports Significant Decrease in Net Loss to $1.98M for 2024, Driven by Lower Operating Costs and Increased Other Income

NLS Pharmaceutics Announces Board Resignation Amid Restructuring Efforts

NLS Pharmaceutics Study Suggests Mazindol May Help Treat Fentanyl Use Disorder

MT Newswires Live

NLS Pharmaceutics Reports Positive Results in Fentanyl Study

BRIEF-Nls Pharmaceutics Announces Positive Results From Study Ko-943 Demonstrating Mazindol Reduces Fentanyl-Induced Reward In Animal Models

NLS Pharmaceutics’ Mazindol reduces fentanyl-induced reward in animal models

NLS Pharmaceutics Announces Positive Results From Study Ko-943 Demonstrating Mazindol Reduces Fentanyl-Induced Reward in Animal Models

THOMSON REUTERS

Press Release: NLS Pharmaceutics Announces Positive Results from Study KO-943 Demonstrating Mazindol Reduces Fentanyl-Induced Reward in Animal Models

NLS Pharmaceutics Announces Strategic Merger and Advances in Therapeutic Pipeline

Press Release: NLS Pharmaceutics CEO Issues Letter to Shareholders

NLS Pharmaceutics Announces New Preclinical Data for AEX-2, Expanding the Therapeutic Potential of its Non-Sulfonamide Dual Orexin Receptor Agonist Platform

NLS Pharmaceutics and Kadimastem complete pre-IND diabetes meeting with FDA

Kadimastem and Itolerance Successfully Complete Pre-Ind Meeting With the FDA for Its Type 1 Diabetes Treatment

THOMSON REUTERS

Kadimastem and iTolerance Successfully Complete Pre-IND Meeting with the FDA for its Type 1 Diabetes Treatment

NLS Pharmaceutics files $75M mixed securities shelf

BRIEF-NLS Pharmaceutics And Kadimastem Unveil Multi-Target Approach To Diabetes

NLS Pharmaceutics and Kadimastem Announce Merger to Innovate Diabetes Treatment

NLS Pharmaceutics and Kadimastem Unveil Multi-Target Approach to Diabetes, Expanding Beyond Glp-1 Therapies

THOMSON REUTERS

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The Fourth Amendment to the Agreement of Merger and Plan of Reorganization, dated June 5, 2025, outlines changes to the terms of the merger. Key amendments include updates to the calculation of the merger consideration, with detailed provisions for estimating closing indebtedness, cash, and adjusted cash amounts by NLS Pharmaceutics. The updated agreement reflects the collaborative efforts of the involved parties to ensure a smooth transition and integration process.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. NLS Pharmaceutics Ltd. published the original content used to generate this news brief via EDGA","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250606:nNDL73yhhH:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"corporation,event","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["NLSP","BK4007"],"gpt_icon":0},{"id":"2537987069","title":"NLS Pharmaceutics to present new preclinical data on Mazindol ER at ASCP","url":"https://stock-news.laohu8.com/highlight/detail?id=2537987069","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2537987069?lang=en_us&edition=fundamental","pubTime":"2025-05-21 19:35","pubTimestamp":1747827332,"startTime":"0","endTime":"0","summary":"NLS Pharmaceutics (NLSP) announces that it will present new preclinical data on Mazindol ER at the 2025 Annual Meeting of the American Society of C...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/nls-pharmaceutics-to-present-new-preclinical-data-on-mazindol-er-at-ascp?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/nls-pharmaceutics-to-present-new-preclinical-data-on-mazindol-er-at-ascp?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["NLSP","BK4007"],"gpt_icon":0},{"id":"2536340383","title":"NLS Pharmaceutics AG Reports Significant Decrease in Net Loss to $1.98M for 2024, Driven by Lower Operating Costs and Increased Other Income","url":"https://stock-news.laohu8.com/highlight/detail?id=2536340383","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2536340383?lang=en_us&edition=fundamental","pubTime":"2025-05-17 04:03","pubTimestamp":1747425780,"startTime":"0","endTime":"0","summary":"NLS Pharmaceutics AG Reports Significant Decrease in Net Loss to $1.98M for 2024, Driven by Lower Operating Costs and Increased Other Income. 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On April 18, 2025, Audrey Greenberg resigned from the Board of Directors of NLS Pharmaceutics...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/company-announcements/nls-pharmaceutics-announces-board-resignation-amid-restructuring-efforts?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/company-announcements/nls-pharmaceutics-announces-board-resignation-amid-restructuring-efforts?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"executive","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["NLSP","BK4007"],"gpt_icon":0},{"id":"2527449018","title":"NLS Pharmaceutics Study Suggests Mazindol May Help Treat Fentanyl Use Disorder","url":"https://stock-news.laohu8.com/highlight/detail?id=2527449018","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2527449018?lang=en_us&edition=fundamental","pubTime":"2025-04-15 23:13","pubTimestamp":1744729999,"startTime":"0","endTime":"0","summary":"NLS Pharmaceutics  said Tuesday its preclinical investigation provides evidence that Mazindol may offer a novel, non-opioid approach for the treatment of fentanyl use disorder.The study, which assessed the rewarding effects of fentanyl and the impact of Mazindol in mice, showed that Mazindol significantly reduced fentanyl-induced conditioned place preference, the company said.Shares of NLS Pharmaceutics were up nearly 3% in recent trading.Price: 1.49, Change: +0.04, Percent Change: +2.90","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["NLSP","BK4007"],"gpt_icon":0},{"id":"2527412280","title":"NLS Pharmaceutics Reports Positive Results in Fentanyl Study","url":"https://stock-news.laohu8.com/highlight/detail?id=2527412280","media":"TIPRANKS","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2527412280?lang=en_us&edition=fundamental","pubTime":"2025-04-15 21:27","pubTimestamp":1744723670,"startTime":"0","endTime":"0","summary":"The latest update is out from NLS Pharmaceutics ( ($NLSP) ). On April 15, 2025, NLS Pharmaceutics announced positive results from a preclinical stu...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/company-announcements/nls-pharmaceutics-reports-positive-results-in-fentanyl-study?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/company-announcements/nls-pharmaceutics-reports-positive-results-in-fentanyl-study?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["NLSP","BK4007"],"gpt_icon":0},{"id":"2527411645","title":"BRIEF-Nls Pharmaceutics Announces Positive Results From Study Ko-943 Demonstrating Mazindol Reduces Fentanyl-Induced Reward In Animal Models","url":"https://stock-news.laohu8.com/highlight/detail?id=2527411645","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2527411645?lang=en_us&edition=fundamental","pubTime":"2025-04-15 21:13","pubTimestamp":1744722795,"startTime":"0","endTime":"0","summary":"BRIEF-Nls Pharmaceutics Announces Positive Results From Study Ko-943 Demonstrating Mazindol Reduces Fentanyl-Induced Reward In Animal ModelsApril 15 (Reuters) - Kadimastem Ltd KDST.TA:NLS PHARMACEUTIC","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250415:nFWN3QT0Z4:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["NLSP"],"gpt_icon":0},{"id":"2527414363","title":"NLS Pharmaceutics’ Mazindol reduces fentanyl-induced reward in animal models","url":"https://stock-news.laohu8.com/highlight/detail?id=2527414363","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2527414363?lang=en_us&edition=fundamental","pubTime":"2025-04-15 21:06","pubTimestamp":1744722395,"startTime":"0","endTime":"0","summary":"NLS Pharmaceutics (NLSP) announced positive results from Study KO-943, a preclinical investigation evaluating the efficacy of Mazindol in mitigatin...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/nls-pharmaceutics-mazindol-reduces-fentanyl-induced-reward-in-animal-models?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/nls-pharmaceutics-mazindol-reduces-fentanyl-induced-reward-in-animal-models?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["LU0661504455.SGD","BK4559","IE00BVYPNV92.GBP","LU0098860793.USD","LU2506952170.USD","SG9999015358.SGD","BK4588","NLSP","LU1732799900.SGD","LU2237957902.USD","SG9999002232.USD","LU1670710588.SGD","BK4610","LU1988902786.USD","LU1059921491.USD","LU2279689827.SGD","LU2506951958.HKD","LU2237443549.SGD","LU2125154935.USD","LU0323591593.USD","LU0823417737.USD","LU0545039389.USD","LU0795875169.SGD","SG9999014542.SGD","LU1815333072.USD","LU0234572021.USD","SG9999003800.SGD","LU0795875086.SGD","LU0289960550.SGD","SG9999002224.SGD","LU2506951875.HKD","LU0957791311.USD","LU1196500208.SGD","LU0096364046.USD","BK4533","LU0175139822.USD","IE00BGHQF631.EUR","LU1162221912.USD","LU0553294199.USD","LU2264538146.SGD","SG9999015341.SGD","BK4177","LU1732800096.USD","SG9999004303.SGD","BK4007","LU1718418525.SGD","SG9999014559.SGD","IE00B42XCP33.USD","SG9999014575.USD"],"gpt_icon":0},{"id":"2527419659","title":"NLS Pharmaceutics Announces Positive Results From Study Ko-943 Demonstrating Mazindol Reduces Fentanyl-Induced Reward in Animal Models","url":"https://stock-news.laohu8.com/highlight/detail?id=2527419659","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2527419659?lang=en_us&edition=fundamental","pubTime":"2025-04-15 21:00","pubTimestamp":1744722012,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250415:nFWN3QT0Z4:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["NLSP","BK4007"],"gpt_icon":0},{"id":"2527841992","title":"Press Release: NLS Pharmaceutics Announces Positive Results from Study KO-943 Demonstrating Mazindol Reduces Fentanyl-Induced Reward in Animal Models","url":"https://stock-news.laohu8.com/highlight/detail?id=2527841992","media":"Dow Jones","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2527841992?lang=en_us&edition=fundamental","pubTime":"2025-04-15 21:00","pubTimestamp":1744722000,"startTime":"0","endTime":"0","summary":"Non-opioid, multi-mechanism profile positions Mazindol as a differentiated asset in addiction therapeutics. Favorable results support potential expansion into high-value markets beyond ADHD and narcolepsy. Study KO-943 utilized a validated CPP paradigm in C57BL/6J mice to measure the rewarding properties of fentanyl and the modulatory effects of Mazindol. Mice were divided into four groups: vehicle control, fentanyl-only , and fentanyl with Mazindol co-treatment . The primary outcome measured was the change in time spent in the drug-paired compartment after conditioning.\"We believe that these data provide compelling evidence of the multi-target potential of Mazindol to address the opioid crisis through a novel mechanism of action,\" said Dr. Eric Konofal, MD, PhD, Chief Scientific Officer of NLS Pharmaceutics. \"By targeting key pathways--including partial mu-opioid receptor  agonism, serotonin 5-HT1A modulation, and orexin-2 receptor  activity--Mazindol offers a robust and differentiate","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":"Press Release: NLS Pharmaceutics Announces Positive Results from Study KO-943 Demonstrating Mazindol Reduces Fentanyl-Induced Reward in Animal Models","news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["NLSP"],"gpt_icon":1},{"id":"2518227127","title":"NLS Pharmaceutics Announces Strategic Merger and Advances in Therapeutic Pipeline","url":"https://stock-news.laohu8.com/highlight/detail?id=2518227127","media":"TIPRANKS","labels":["merge"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2518227127?lang=en_us&edition=fundamental","pubTime":"2025-03-10 21:48","pubTimestamp":1741614517,"startTime":"0","endTime":"0","summary":"NLS Pharmaceutics ( ($NLSP) ) has issued an announcement. On March 10, 2025, NLS Pharmaceutics announced significant strategic milestones, includin...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/company-announcements/nls-pharmaceutics-announces-strategic-merger-and-advances-in-therapeutic-pipeline?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/company-announcements/nls-pharmaceutics-announces-strategic-merger-and-advances-in-therapeutic-pipeline?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"merge","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["NLSP","BK4007"],"gpt_icon":0},{"id":"2518241019","title":"Press Release: NLS Pharmaceutics CEO Issues Letter to Shareholders","url":"https://stock-news.laohu8.com/highlight/detail?id=2518241019","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2518241019?lang=en_us&edition=fundamental","pubTime":"2025-03-10 19:00","pubTimestamp":1741604400,"startTime":"0","endTime":"0","summary":"ZURICH, March 10, 2025 /PRNewswire/ -- NLS Pharmaceutics Ltd. , a Swiss clinical-stage biopharmaceutical company focused on developing innovative therapies for central nervous system  disorders, today issued a letter to its shareholders.We are thrilled to share the significant progress and strategic milestones NLS Pharmaceutics has achieved, positioning our company for a transformative future in the biotechnology sector.In collaboration with iTolerance Inc., Kadimastem has successfully completed a pre-Investigational New Drug  meeting with the U.S. Food and Drug Administration  for iTOL-102, a potential breakthrough therapy for Type 1 Diabetes. This innovative approach combines Kadimastem's IsletRx cells with iTolerance's immunomodulator, aiming to cure Type 1 Diabetes without the need for lifelong immune suppression.The diabetes treatment landscape has experienced significant growth, underscored by notable mergers and acquisitions. For instance, Novo Nordisk's acquisition of Inversago","market":"sg","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["CNS","USAW.SI","BK4022","NVIW.SI","NQmain","R","MNQmain","USJW.SI","BK4232","QLD","PSQ","QID","BK4007","NLSP","TQQQ","SQQQ","TSYW.SI",".IXIC","BK4135"],"gpt_icon":1},{"id":"2514059108","title":"NLS Pharmaceutics Announces New Preclinical Data for AEX-2, Expanding the Therapeutic Potential of its Non-Sulfonamide Dual Orexin Receptor Agonist Platform","url":"https://stock-news.laohu8.com/highlight/detail?id=2514059108","media":"PR Newswire","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2514059108?lang=en_us&edition=fundamental","pubTime":"2025-02-27 20:00","pubTimestamp":1740657600,"startTime":"0","endTime":"0","summary":"ZRICH, Switzerland, Feb. 27, 2025 /PRNewswire/ -- NLS Pharmaceutics Ltd.   , in collaboration with Aexon Labs Inc. , is pleased to announce new preclinical findings on AEX-2, reinforcing its potential as a first-in-class non-sulfonamide dual orexin receptor agonist  for narcolepsy and related neurological disorders. These results build upon the Company's multi-target neurodegenerative strategy, which also includes AEX-41, demonstrating a novel and promising approach to addressing sleep disorders, neuroinflammation, and metabolic dysfunction.Recent preclinical advancements have demonstrated the multi-target potential of DOXA compounds, including AEX-41 and AEX-2, in redefining sleep-wake regulation and neuroprotection. In orexin-deficient mouse models, these compounds exhibited strong wake-promoting effects and sleep-wake cycle stabilization, reinforcing their potential as next-generation therapeutics. Key findings include:. 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