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NLS Pharmaceutics Ltd.

2.86

-0.0400-1.38%

Post-market: 2.14-0.7200-25.17%19:59 EDT

Volume:590.67K

Turnover:1.74M

Market Cap:10.29M

PE:-0.43

High:3.03

Open:2.96

Low:2.76

Close:2.90

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Overview Company News Filings

Press Release: NLS Pharmaceutics Announces Positive Results from Study KO-943 Demonstrating Mazindol Reduces Fentanyl-Induced Reward in Animal Models

NLS Pharmaceutics Announces Strategic Merger and Advances in Therapeutic Pipeline

Press Release: NLS Pharmaceutics CEO Issues Letter to Shareholders

NLS Pharmaceutics Announces New Preclinical Data for AEX-2, Expanding the Therapeutic Potential of its Non-Sulfonamide Dual Orexin Receptor Agonist Platform

NLS Pharmaceutics and Kadimastem complete pre-IND diabetes meeting with FDA

Kadimastem and Itolerance Successfully Complete Pre-Ind Meeting With the FDA for Its Type 1 Diabetes Treatment

THOMSON REUTERS

Kadimastem and iTolerance Successfully Complete Pre-IND Meeting with the FDA for its Type 1 Diabetes Treatment

NLS Pharmaceutics files $75M mixed securities shelf

BRIEF-NLS Pharmaceutics And Kadimastem Unveil Multi-Target Approach To Diabetes

NLS Pharmaceutics and Kadimastem Announce Merger to Innovate Diabetes Treatment

NLS Pharmaceutics and Kadimastem Unveil Multi-Target Approach to Diabetes, Expanding Beyond Glp-1 Therapies

THOMSON REUTERS

NLS Pharmaceutics Amends Merger Agreement with Kadimastem

Dow Edges Lower; Exxon Mobil Earnings Top Views

NLS Pharmaceutics Says Kadimastem Shareholders Approve Merger With NLS; Shares Rise

MT Newswires Live

Kadimastem Shareholders Approved the Merger With NLS Pharmaceutics

THOMSON REUTERS

NLS Pharmaceutics Submits Research Abstracts to ASCP 2025

NLS Pharmaceutics Announces the Submission of Three Research Abstracts to the 2025 ASCP Annual Meeting

NLS Pharmaceutics Launches Preclinical Program for Fentanyl Dependence Treatment

NLS Pharmaceutics Announces the Launch of a Preclinical Program for Mazindol Er in the Treatment of Fentanyl Dependence

THOMSON REUTERS

Kadimastem Calls for a Special General Meeting of Shareholders to Approve the Merger With NLS

THOMSON REUTERS

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Favorable results support potential expansion into high-value markets beyond ADHD and narcolepsy. Study KO-943 utilized a validated CPP paradigm in C57BL/6J mice to measure the rewarding properties of fentanyl and the modulatory effects of Mazindol. Mice were divided into four groups: vehicle control, fentanyl-only , and fentanyl with Mazindol co-treatment . The primary outcome measured was the change in time spent in the drug-paired compartment after conditioning.\"We believe that these data provide compelling evidence of the multi-target potential of Mazindol to address the opioid crisis through a novel mechanism of action,\" said Dr. Eric Konofal, MD, PhD, Chief Scientific Officer of NLS Pharmaceutics. \"By targeting key pathways--including partial mu-opioid receptor  agonism, serotonin 5-HT1A modulation, and orexin-2 receptor  activity--Mazindol offers a robust and differentiate","market":"sg","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":"Press Release: NLS Pharmaceutics Announces Positive Results from Study KO-943 Demonstrating Mazindol Reduces Fentanyl-Induced Reward in Animal Models","news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["NLSP"],"gpt_icon":1},{"id":"2518227127","title":"NLS Pharmaceutics Announces Strategic Merger and Advances in Therapeutic Pipeline","url":"https://stock-news.laohu8.com/highlight/detail?id=2518227127","media":"TIPRANKS","labels":["merge"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2518227127?lang=en_us&edition=fundamental","pubTime":"2025-03-10 21:48","pubTimestamp":1741614517,"startTime":"0","endTime":"0","summary":"NLS Pharmaceutics ( ($NLSP) ) has issued an announcement. On March 10, 2025, NLS Pharmaceutics announced significant strategic milestones, includin...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/company-announcements/nls-pharmaceutics-announces-strategic-merger-and-advances-in-therapeutic-pipeline?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/company-announcements/nls-pharmaceutics-announces-strategic-merger-and-advances-in-therapeutic-pipeline?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"merge","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["NLSP","BK4007"],"gpt_icon":0},{"id":"2518241019","title":"Press Release: NLS Pharmaceutics CEO Issues Letter to Shareholders","url":"https://stock-news.laohu8.com/highlight/detail?id=2518241019","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2518241019?lang=en_us&edition=fundamental","pubTime":"2025-03-10 19:00","pubTimestamp":1741604400,"startTime":"0","endTime":"0","summary":"ZURICH, March 10, 2025 /PRNewswire/ -- NLS Pharmaceutics Ltd. , a Swiss clinical-stage biopharmaceutical company focused on developing innovative therapies for central nervous system  disorders, today issued a letter to its shareholders.We are thrilled to share the significant progress and strategic milestones NLS Pharmaceutics has achieved, positioning our company for a transformative future in the biotechnology sector.In collaboration with iTolerance Inc., Kadimastem has successfully completed a pre-Investigational New Drug  meeting with the U.S. Food and Drug Administration  for iTOL-102, a potential breakthrough therapy for Type 1 Diabetes. This innovative approach combines Kadimastem's IsletRx cells with iTolerance's immunomodulator, aiming to cure Type 1 Diabetes without the need for lifelong immune suppression.The diabetes treatment landscape has experienced significant growth, underscored by notable mergers and acquisitions. For instance, Novo Nordisk's acquisition of Inversago","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["R","TSYW.SI","CNS","TQQQ","BK4022","NQmain","BK4007","USJW.SI","NLSP","USAW.SI","NVIW.SI","MNQmain","BK4135","BK4232","PSQ","QID",".IXIC","QLD","SQQQ"],"gpt_icon":1},{"id":"2514059108","title":"NLS Pharmaceutics Announces New Preclinical Data for AEX-2, Expanding the Therapeutic Potential of its Non-Sulfonamide Dual Orexin Receptor Agonist Platform","url":"https://stock-news.laohu8.com/highlight/detail?id=2514059108","media":"PR Newswire","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2514059108?lang=en_us&edition=fundamental","pubTime":"2025-02-27 20:00","pubTimestamp":1740657600,"startTime":"0","endTime":"0","summary":"ZRICH, Switzerland, Feb. 27, 2025 /PRNewswire/ -- NLS Pharmaceutics Ltd.   , in collaboration with Aexon Labs Inc. , is pleased to announce new preclinical findings on AEX-2, reinforcing its potential as a first-in-class non-sulfonamide dual orexin receptor agonist  for narcolepsy and related neurological disorders. These results build upon the Company's multi-target neurodegenerative strategy, which also includes AEX-41, demonstrating a novel and promising approach to addressing sleep disorders, neuroinflammation, and metabolic dysfunction.Recent preclinical advancements have demonstrated the multi-target potential of DOXA compounds, including AEX-41 and AEX-2, in redefining sleep-wake regulation and neuroprotection. In orexin-deficient mouse models, these compounds exhibited strong wake-promoting effects and sleep-wake cycle stabilization, reinforcing their potential as next-generation therapeutics. Key findings include:. Wakefulness Enhancement: AEX-2 significantly increased total w","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"yahoofinance","url":"https://finance.yahoo.com/news/nls-pharmaceutics-announces-preclinical-data-120000386.html","rn_cache_url":null,"customStyle":"img, svg { display: none !important; }","selectors":"article","filters":"","directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/nls-pharmaceutics-announces-preclinical-data-120000386.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["NLSPW","BK4007","NLSP"],"gpt_icon":0},{"id":"2514097571","title":"NLS Pharmaceutics and Kadimastem complete pre-IND diabetes meeting with FDA","url":"https://stock-news.laohu8.com/highlight/detail?id=2514097571","media":"TIPRANKS","labels":["corporation"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2514097571?lang=en_us&edition=fundamental","pubTime":"2025-02-25 22:10","pubTimestamp":1740492613,"startTime":"0","endTime":"0","summary":"NLS Pharmaceutics (NLSP) and Kadimastem, a clinical-stage company specializing in “off-the-shelf” allogeneic cell therapy products for neurodegener...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/nls-pharmaceutics-and-kadimastem-complete-pre-ind-diabetes-meeting-with-fda?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/nls-pharmaceutics-and-kadimastem-complete-pre-ind-diabetes-meeting-with-fda?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"corporation","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4007","NLSP"],"gpt_icon":0},{"id":"2514375092","title":"Kadimastem and Itolerance Successfully Complete Pre-Ind Meeting With the FDA for Its Type 1 Diabetes Treatment","url":"https://stock-news.laohu8.com/highlight/detail?id=2514375092","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2514375092?lang=en_us&edition=fundamental","pubTime":"2025-02-25 22:05","pubTimestamp":1740492315,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250225:nTUA9YBWXT:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["NLSP","BK4007"],"gpt_icon":0},{"id":"2514097312","title":"Kadimastem and iTolerance Successfully Complete Pre-IND Meeting with the FDA for its Type 1 Diabetes Treatment","url":"https://stock-news.laohu8.com/highlight/detail?id=2514097312","media":"PR Newswire","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2514097312?lang=en_us&edition=fundamental","pubTime":"2025-02-25 22:05","pubTimestamp":1740492300,"startTime":"0","endTime":"0","summary":"Companies Advance Collaborative Clinical Development of iTOL-102: A Potential Cure for Diabetes Without the Need for Chronic Life-long Immune Suppression. ZURICH and NESSZIONA, Israel, Feb. 25, 2025 /PRNewswire/ -- NLS Pharmaceutics Ltd.   and Kadimastem Ltd.  , a clinical-stage company specializing in \"off-the-shelf\" allogeneic cell therapy products for neurodegenerative diseases and diabetes, in collaboration with iTolerance Inc. , a U.S. based regenerative medicine company, announced today the result from the Type B pre-IND meeting held by Kadimastem and iTolerance with a committee of the U.S Food and Drug Administration  on February 24, 2025, regarding the development of iTOL-102, a potential cure for diabetes that would not require life-long chronic immune system suppression. iTOL-102 is an investigational biologic for the treatment and potential cure of Type 1 Diabetes consisting of Kadimastem's allogenic human stem cell-derived pancreatic islets  combined with iTolerance's immun","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"yahoofinance","url":"https://finance.yahoo.com/news/kadimastem-itolerance-successfully-complete-pre-140500332.html","rn_cache_url":null,"customStyle":"img, svg { display: none !important; }","selectors":"article","filters":"","directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/kadimastem-itolerance-successfully-complete-pre-140500332.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["NLSP","KMSTF","NLSPW","BK4139"],"gpt_icon":0},{"id":"2510681901","title":"NLS Pharmaceutics files $75M mixed securities shelf","url":"https://stock-news.laohu8.com/highlight/detail?id=2510681901","media":"TIPRANKS","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2510681901?lang=en_us&edition=fundamental","pubTime":"2025-02-11 06:50","pubTimestamp":1739227830,"startTime":"0","endTime":"0","summary":"17:45 EST NLS Pharmaceutics (NLSP) files $75M mixed securities shelf Published first on TheFly – the ultimate source for real-time, market-moving b...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/nls-pharmaceutics-files-75m-mixed-securities-shelf?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/nls-pharmaceutics-files-75m-mixed-securities-shelf?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4007","NLSP"],"gpt_icon":0},{"id":"2510374857","title":"BRIEF-NLS Pharmaceutics And Kadimastem Unveil Multi-Target Approach To Diabetes","url":"https://stock-news.laohu8.com/highlight/detail?id=2510374857","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2510374857?lang=en_us&edition=fundamental","pubTime":"2025-02-10 21:43","pubTimestamp":1739195024,"startTime":"0","endTime":"0","summary":"BRIEF-NLS Pharmaceutics And Kadimastem Unveil Multi-Target Approach To DiabetesFeb 10 (Reuters) - Kadimastem KDST.TA:NLS PHARMACEUTICS AND KADIMASTEM UNVEIL MULTI-TARGET APPROACH TO DIABETES, EXPANDIN","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250210:nFWN3P10V8:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4007","NLSP"],"gpt_icon":0},{"id":"2510854147","title":"NLS Pharmaceutics and Kadimastem Announce Merger to Innovate Diabetes Treatment","url":"https://stock-news.laohu8.com/highlight/detail?id=2510854147","media":"TIPRANKS","labels":["corporation","merge"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2510854147?lang=en_us&edition=fundamental","pubTime":"2025-02-10 21:07","pubTimestamp":1739192854,"startTime":"0","endTime":"0","summary":"An update from NLS Pharmaceutics ( ($NLSP) ) is now available. On February 10, 2025, NLS Pharmaceutics Ltd. announced a strategic merger with Kadim...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/company-announcements/nls-pharmaceutics-and-kadimastem-announce-merger-to-innovate-diabetes-treatment?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/company-announcements/nls-pharmaceutics-and-kadimastem-announce-merger-to-innovate-diabetes-treatment?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"corporation,merge","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4007","NLSP"],"gpt_icon":0},{"id":"2510859922","title":"NLS Pharmaceutics and Kadimastem Unveil Multi-Target Approach to Diabetes, Expanding Beyond Glp-1 Therapies","url":"https://stock-news.laohu8.com/highlight/detail?id=2510859922","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2510859922?lang=en_us&edition=fundamental","pubTime":"2025-02-10 20:30","pubTimestamp":1739190610,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250210:nFWN3P10V8:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4007","NLSP"],"gpt_icon":0},{"id":"2508990725","title":"NLS Pharmaceutics Amends Merger Agreement with Kadimastem","url":"https://stock-news.laohu8.com/highlight/detail?id=2508990725","media":"TIPRANKS","labels":["corporation","merge"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2508990725?lang=en_us&edition=fundamental","pubTime":"2025-02-01 05:27","pubTimestamp":1738358872,"startTime":"0","endTime":"0","summary":"NLS Pharmaceutics ( ($NLSP) ) just unveiled an update. 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