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total product revenues of $922 million in Q1'25 . – Jakafi  net product revenues of $709 million in Q1'25 ; increasing full year 2025 Jakafi guidance to a new range of $2,950 - $3,000 million from $2,925 - $2,975 million. – Opzelura  cream net product revenues of $119 million in Q1'25 . – Niktimvo  net product revenues of $14 million in the first two months of U.S. launch demonstrating strong commercial execution and high patient need. – New, 18-week data from ongoing Phase 3 study of povorcitinib in hidradenitis suppurativa  demonstrates continued improvement in HiSCR from Week 12 in addition to high response rates in placebo-crossover patients. – Positive Phase 2 topline results for povorcitinib in chronic spontaneous urticaria  demonstrates proof-of-concept in new indication. 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