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ASCLETIS-B

7.650

-0.070-0.91%

Volume:5.47M

Turnover:41.23M

Market Cap:7.37B

PE:-23.32

High:7.790

Open:7.380

Low:7.220

Close:7.720

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Overview Company News Filings

HK Movers｜Pharma Shares Rallied. CSPC Pharma Up 9%; 3SBio Up 4%; Yihai Up 3%; Genscript Bio And JXR Up 2%.

Tiger Newspress

HK Movers｜HK Pharma Shares Kept Rally. Zai Lab Up 7%; Hutchmed Up 6%; Immunotech Up 5%

Tiger Newspress

BUZZ-Sagimet soars as oral acne drug aces late-stage trial in China

Sagimet Biosciences Shares Jump 52% Premarket After Oral Acne Drug With Partner Ascletis Met the Main Goals in a Late-Stage Trial

THOMSON REUTERS

Sagimet Biosciences Announces Positive Phase 3 Results for Denifanstat in Treating Moderate-to-Severe Acne

HK Movers｜Pharma Shares Jumped. Innovent Bio Up 15%; Zai Lab Up 5%; Junshi Bio And CSPC Pharma Up 4%

Tiger Newspress

Ascletis Pharma Announces Successful Phase III Trial of Denifanstat, a Groundbreaking Oral FASN Inhibitor for Acne Treatment

Ascletis Announces Phase Iii Trial of Denifanstat (Asc40), a First-in-Class, Once-Daily Oral Fasn Inhibitor for Acne, Meets All Endpoints

THOMSON REUTERS

Ascletis Pharma Inc - Announces Phase Iii Trial of Denifanstat Meets All Endpoints

THOMSON REUTERS

HK Movers｜HK's Pharma Shares Jumped. Medlive Up 8%; Sihuan Pharm And Junshi Bio Up 7%; Pharmaron And Fosun Pharma Up 5%

Tiger Newspress

Ascletis Pharma Faces Legal Setback with Seven-Year Exclusion Order for ASC41 and ASC43F Drugs

HK Movers | Biopharmaceutical Stocks Jump With SinoMab BioScience up 18%

Tiger Newspress

Ascletis Pharma's Application for Plaque Psoriasis Drug Cleared by US FDA

MT Newswires Live

BRIEF-Ascletis Announces U.S. FDA Clearance Of Ind Application For Its Oral Small Molecule Il-17 Inhibitor, ASC50, For The Treatment Of Psoriasis

BRIEF-Ascletis Pharma Says US FDA Cleared IND Application For Oral Small Molecule IL-17 Inhibitor, ASC50

Ascletis Announces U.S. FDA Clearance of Ind Application for Its Oral Small Molecule Il-17 Inhibitor, Asc50, for the Treatment of Psoriasis

THOMSON REUTERS

Ascletis Pharma Inc - Phase I Trial Dosing Expected to Start in Q3 2025

THOMSON REUTERS

Ascletis Pharma Inc. Announces FDA Clearance for Phase I Trial of ASC50, a Promising Oral IL-17 Inhibitor for Psoriasis Treatment

Ascletis Pharma Inc - U.S. FDA Clearance of Ind Application for Oral Small Molecule Il-17 Inhibitor, Asc50

THOMSON REUTERS

Ascletis Pharma Inc. Conducted Annual General Meeting

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CSPC Pharma Up 9%; 3SBio Up 4%; Yihai Up 3%; Genscript Bio And JXR Up 2%.","url":"https://stock-news.laohu8.com/highlight/detail?id=1102844514","media":"Tiger Newspress","labels":["movement"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/1102844514?lang=en_us&edition=fundamental","pubTime":"2025-06-06 14:14","pubTimestamp":1749190451,"startTime":"0","endTime":"0","summary":"HK pharma shares rallied. CSPC Pharma up 9%; 3SBio up 4%; Yihai up 3%; Genscript Bio and JXR up 2%.","market":"hk","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":"","theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":true,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"movement","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["02269","01672","02268","03759","06978","09966","03347","02359","09995","06606","02137","09606","09688"],"gpt_icon":0},{"id":"1147990132","title":"HK Movers｜HK Pharma Shares Kept Rally. Zai Lab Up 7%; Hutchmed Up 6%; Immunotech Up 5%","url":"https://stock-news.laohu8.com/highlight/detail?id=1147990132","media":"Tiger Newspress","labels":["movement"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/1147990132?lang=en_us&edition=fundamental","pubTime":"2025-06-05 10:17","pubTimestamp":1749089820,"startTime":"0","endTime":"0","summary":"HK pharma shares kept rally. Zai Lab up 7%; Hutchmed up 6%; Immunotech up 5%; Sihuan Pharm, Akeso and Genscript Bio up 4%.","market":"hk","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":"","theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":true,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"movement","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["03759","02359","09688","02268","06606","03347","06978","02137","09606","02269","09966","09995","01672"],"gpt_icon":0},{"id":"2540055112","title":"BUZZ-Sagimet soars as oral acne drug aces late-stage trial in China","url":"https://stock-news.laohu8.com/highlight/detail?id=2540055112","media":"Reuters","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2540055112?lang=en_us&edition=fundamental","pubTime":"2025-06-04 17:27","pubTimestamp":1749029233,"startTime":"0","endTime":"0","summary":"BUZZ-Sagimet soars as oral acne drug aces late-stage trial in China** Shares of drug developer Sagimet Biosciences SGMT.O rise 52% to $5.53 premarket** SGMT says its oral acne drug, denifanstat, met the main goals in a late-stage trial conducted by its Chinese partner Ascletis 1672.HK** Denifanstat showed 33.2% treatment success rate versus 14.6% for placebo** Denifanstat works by inhibiting the production of sebum, a key contributor to acne, through a novel mechanism of action, co says** The drug reduced total acne lesions by 57.4% compared to 35.4% with placebo** Ascletis plans to submit denifanstat for approval to Chinese regulators** As of last close, stock down 19.3% YTD  ","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250604:nL3N3S70LM:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"2","news_top_title":null,"news_tag":"productRelease","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SGMT","BK1161","BK1574","01672","BK1515","BK4139"],"gpt_icon":0},{"id":"2540055977","title":"Sagimet Biosciences Shares Jump 52% Premarket After Oral Acne Drug With Partner Ascletis Met the Main Goals in a Late-Stage Trial","url":"https://stock-news.laohu8.com/highlight/detail?id=2540055977","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2540055977?lang=en_us&edition=fundamental","pubTime":"2025-06-04 17:15","pubTimestamp":1749028555,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250604:nFWN3S70BL:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK1574","BK1161","BK1515","01672","SGMT","BK4139"],"gpt_icon":0},{"id":"2540053848","title":"Sagimet Biosciences Announces Positive Phase 3 Results for Denifanstat in Treating Moderate-to-Severe Acne","url":"https://stock-news.laohu8.com/highlight/detail?id=2540053848","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2540053848?lang=en_us&edition=fundamental","pubTime":"2025-06-04 17:00","pubTimestamp":1749027616,"startTime":"0","endTime":"0","summary":"Sagimet Biosciences Inc., a clinical-stage biopharmaceutical company, announced the positive results of a Phase 3 clinical trial conducted by its license partner, Ascletis Bioscience Co. Ltd. in China, for the treatment of moderate to severe acne vulgaris. The trial evaluated the oral small molecule fatty acid synthase  inhibitor, denifanstat, which met all primary and secondary endpoints versus a placebo and was well tolerated by participants. This development marks an advancement in acne treatment, introducing a novel mechanism of action through FASN inhibition. Additionally, Sagimet has initiated a Phase 1 clinical trial in the United States for a second FASN inhibitor, TVB-3567, targeting acne treatment. The positive outcomes from the trial underscore the potential of FASN inhibition as a therapeutic approach for acne.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely informatio","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250604:nNDL9NgkYx:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"2","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["01672","BK1574","BK4112","BK1515","BK4588","BK4139","LU2210149790.SGD","IE00BKPKM429.USD","LU2210150020.SGD","LU2095319765.USD","IE00B3QW5Z07.USD","IE00BGHQF748.EUR","NDAQ","BK4585","SGMT","BK1161","IE00B64PRP62.GBP"],"gpt_icon":0},{"id":"1129441589","title":"HK Movers｜Pharma Shares Jumped. Innovent Bio Up 15%; Zai Lab Up 5%; Junshi Bio And CSPC Pharma Up 4%","url":"https://stock-news.laohu8.com/highlight/detail?id=1129441589","media":"Tiger Newspress","labels":["movement"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/1129441589?lang=en_us&edition=fundamental","pubTime":"2025-06-04 09:41","pubTimestamp":1749001285,"startTime":"0","endTime":"0","summary":"HK's Pharma Shares Jumped. Innovent Bio up 15%; Zai Lab up 5%; Junshi Bio and CSPC Pharma up 4%; TigerMed and Innocare up 3%.","market":"hk","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":"dbe3c8968315be1dd8b4bc2e812eb0a3","theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":true,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"movement","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["02359","09966","09995","02269","03759","01672","02268","03347","02137","06978","09606","09688","06606"],"gpt_icon":0},{"id":"2540088442","title":"Ascletis Pharma Announces Successful Phase III Trial of Denifanstat, a Groundbreaking Oral FASN Inhibitor for Acne Treatment","url":"https://stock-news.laohu8.com/highlight/detail?id=2540088442","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2540088442?lang=en_us&edition=fundamental","pubTime":"2025-06-04 07:15","pubTimestamp":1748992517,"startTime":"0","endTime":"0","summary":"Ascletis Pharma Inc. has announced that its Phase III clinical trial for denifanstat , a first-in-class, once-daily oral fatty acid synthase  inhibitor, has met all primary, key secondary, and secondary endpoints for the treatment of moderate to severe acne vulgaris. The randomized, double-blind, placebo-controlled, multicenter trial conducted in China involved 480 patients. Denifanstat demonstrated a statistically significant improvement in treatment outcomes, with a 33.2% treatment success rate and reductions in total, inflammatory, and non-inflammatory lesion counts by 57.4%, 63.5%, and 51.9% respectively, compared to baseline. The trial results indicate that denifanstat was more effective than several FDA-approved acne treatments in placebo-adjusted percent treatment success. The drug maintained a favorable safety and tolerability profile throughout the study. Ascletis plans to submit the treatment for approval by the China National Medical Products Administration .","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250603:nNDL63QMGf:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["01672","BK1515","BK1574","BK1161"],"gpt_icon":0},{"id":"2540088448","title":"Ascletis Announces Phase Iii Trial of Denifanstat (Asc40), a First-in-Class, Once-Daily Oral Fasn Inhibitor for Acne, Meets All Endpoints","url":"https://stock-news.laohu8.com/highlight/detail?id=2540088448","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2540088448?lang=en_us&edition=fundamental","pubTime":"2025-06-04 07:15","pubTimestamp":1748992502,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250603:nTUA3LVHCD:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["01672","BK1574","BK1515","BK1161"],"gpt_icon":0},{"id":"2540088939","title":"Ascletis Pharma Inc -  Announces Phase Iii Trial of Denifanstat Meets All Endpoints","url":"https://stock-news.laohu8.com/highlight/detail?id=2540088939","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2540088939?lang=en_us&edition=fundamental","pubTime":"2025-06-04 07:00","pubTimestamp":1748991657,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250603:nFWN3S60FU:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK1574","BK1515","01672","BK1161"],"gpt_icon":0},{"id":"1122993430","title":"HK Movers｜HK's Pharma Shares Jumped. Medlive Up 8%; Sihuan Pharm And Junshi Bio Up 7%; Pharmaron And Fosun Pharma Up 5%","url":"https://stock-news.laohu8.com/highlight/detail?id=1122993430","media":"Tiger Newspress","labels":["movement"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/1122993430?lang=en_us&edition=fundamental","pubTime":"2025-06-03 09:40","pubTimestamp":1748914817,"startTime":"0","endTime":"0","summary":"HK's pharma shares jumped. Medlive up 8%; Sihuan Pharm and Junshi Bio up 7%; Pharmaron and Fosun Pharma up 5%.","market":"hk","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":"ca7f89e3633e9b2b6f9adb0439901331","theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":true,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"movement","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["01672","03759","06978","03347","09995","02137","02269","09606","09966","02268","06606","09688","02359"],"gpt_icon":0},{"id":"2539275394","title":"Ascletis Pharma Faces Legal Setback with Seven-Year Exclusion Order for ASC41 and ASC43F Drugs","url":"https://stock-news.laohu8.com/highlight/detail?id=2539275394","media":"Reuters","labels":["policyRegulatory"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2539275394?lang=en_us&edition=fundamental","pubTime":"2025-05-30 22:43","pubTimestamp":1748616210,"startTime":"0","endTime":"0","summary":"Ascletis Pharma Inc. has been involved in legal proceedings with Viking Therapeutics, Inc. over the importation of its drug candidates, ASC41 and ASC43F. In October 2024, the United States International Trade Commission issued an initial determination finding a violation of Section 337, recommending a seven-year exclusion order for these drugs. ASC41 is developed for treating non-alcoholic steatohepatitis  and targets thyroid hormone receptor beta , while ASC43F is a fixed-dose combination targeting both THRβ and farnesoid X receptor  for NASH treatment. Despite the ruling, Ascletis believes the outcome will not have a material adverse effect on its business and is seeking legal advice for an appeal. The company is committed to protecting its trade secrets and will provide updates on any significant developments.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250530:nNDL48bdv9:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"policyRegulatory","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["01672","BK1574","BK4139","BK4588","BK1161","VKTX","BK1515","BK4599","BK4585"],"gpt_icon":0},{"id":"1156294759","title":"HK Movers |  Biopharmaceutical Stocks Jump With SinoMab BioScience up 18%","url":"https://stock-news.laohu8.com/highlight/detail?id=1156294759","media":"Tiger Newspress","labels":["movement"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/1156294759?lang=en_us&edition=fundamental","pubTime":"2025-05-30 11:06","pubTimestamp":1748574369,"startTime":"0","endTime":"0","summary":"Hong Kong-listed biopharmaceutical stocks surged again, with SinoMab BioScience soaring 18%, ImmuneOnco climbing 16%, and Ascletis Pharma rising over 12%. Abbisko, Jacobio Pharm, and HBM Holdings all gained about 4%.","market":"hk","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":"8a007331050a4c5abbca4a26fc55f3d6","theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":true,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"movement","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["02256","01672","01167","02142","03681","01541"],"gpt_icon":0},{"id":"2537943966","title":"Ascletis Pharma's Application for Plaque Psoriasis Drug Cleared by US FDA","url":"https://stock-news.laohu8.com/highlight/detail?id=2537943966","media":"MT Newswires Live","labels":["policyRegulatory"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2537943966?lang=en_us&edition=fundamental","pubTime":"2025-05-22 19:28","pubTimestamp":1747913329,"startTime":"0","endTime":"0","summary":"Ascletis Pharma's  investigational new drug application for a phase I trial for ASC50 for the treatment of mild-to-moderate plaque psoriasis has been cleared by the US Food and Drug Administration , a Thursday Hong Kong bourse filing said.The study will be conducted at multiple sites in the US, with dosing of patients with mild-to-moderate plaque psoriasis expected to start in the third quarter.","market":"sg","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"policyRegulatory","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["01672","BK1574","BK1515","BK1161"],"gpt_icon":0},{"id":"2537948978","title":"BRIEF-Ascletis Announces U.S. FDA Clearance Of Ind Application For Its Oral Small Molecule Il-17 Inhibitor, ASC50, For The Treatment Of Psoriasis","url":"https://stock-news.laohu8.com/highlight/detail?id=2537948978","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2537948978?lang=en_us&edition=fundamental","pubTime":"2025-05-22 19:08","pubTimestamp":1747912093,"startTime":"0","endTime":"0","summary":"BRIEF-Ascletis Announces U.S. FDA Clearance Of Ind Application For Its Oral Small Molecule Il-17 Inhibitor, ASC50, For The Treatment Of PsoriasisMay 22 (Reuters) - 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Announces FDA Clearance for Phase I Trial of ASC50, a Promising Oral IL-17 Inhibitor for Psoriasis Treatment","url":"https://stock-news.laohu8.com/highlight/detail?id=2537944914","media":"Reuters","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2537944914?lang=en_us&edition=fundamental","pubTime":"2025-05-22 17:54","pubTimestamp":1747907643,"startTime":"0","endTime":"0","summary":"Ascletis Pharma Inc. Announces FDA Clearance for Phase I Trial of ASC50, a Promising Oral IL-17 Inhibitor for Psoriasis Treatment. Ascletis Pharma Inc. has announced that the U.S. Food and Drug Administration  has cleared the investigational new drug  application for a Phase I trial of ASC50, an oral small molecule inhibitor targeting interleukin-17 , for the treatment of mild-to-moderate plaque psoriasis. ASC50, discovered and developed in-house by Ascletis, demonstrated favorable preclinical characteristics, including higher drug exposure, longer half-life, and lower clearance in non-human primates compared to existing oral IL-17 inhibitors. The company plans to begin dosing in the Phase I trial during the third quarter of 2025.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. 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