Ascletis reported positive topline results from a U.S. Phase II 24-week obesity study of its ASC30 subcutaneous depot formulation A1 (NCT06679959) in 65 participants. The primary endpoint was met, with placebo-adjusted mean weight loss of 6% at week 12 and 8% at week 16 after three monthly doses. Placebo-adjusted mean weight loss was 6% at week 20 and 6% at week 24, following the final dose at week 8. Ascletis said formulation A1 achieved therapeutic drug exposures in obese patients, while formulation A2 did not.
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