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Summit Therapeutics PLC

24.11

+0.64502.75%

Post-market: 24.180.0700+0.29%19:59 EDT

Volume:13.10M

Turnover:326.02M

Market Cap:17.79B

PE:-77.77

High:26.97

Open:24.38

Low:23.04

Close:23.47

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Overview Company News Filings

Summit Therapeutics Price Target Maintained With a $40.00/Share by JMP Securities

Akeso survival data for ivonescimab misses expectations, STAT says

BUZZ-Summit Therapeutics closes 36% lower after interim data for cancer drug

Summit Therapeutics Is Maintained at Buy by Jefferies

Summit Therapeutics Gets Approval From China's Health Authority for Second Use of Ivonescimab

MT Newswires Live

Summit Therapeutics Shares Resume Trading After Halt, Last Down About 32% at Close to $25

THOMSON REUTERS

Summit Therapeutics trading resumes

Summit Therapeutics to resume trading at 3:20 pm ET

Summit Therapeutics says new ivonescimab data clinically meaningful

Wells says Summit, Akeso data ‘not the bull case,’ but not ‘bear case either’

Summit Therapeutics trading halted, news pending

Summit Therapeutics Inc : Jefferies Raises Target Price to $44 From $31

THOMSON REUTERS

Summit Therapeutics to Host First Quarter 2025 Financial Results & Operational Progress Call on May 1, 2025

Evercore ISI Remains a Buy on Summit Therapeutics (SMMT)

Why Summit Therapeutics Inc. (SMMT) Went Up On Wednesday

Summit Therapeutics Says Phase 3 Cell Lung Cancer Trial Met Primary Endpoint; Shares Rise Pre-Bell

MT Newswires Live

BUZZ-Summit Therapeutics gains as lung cancer drug succeeds in second study in China

S&P 500 Futures Rise In Premarket Trading; Pegasystems, Popular Inc. Lead

Summit Therapeutics Rallies After Lung Cancer Drug Shows Positive Results

Summit Therapeutics Shares up 11.4% Premarket After Co, Partner Akeso's Lung Cancer Treatment Meets Main Goal in Late Stage Trial Conducted in China

THOMSON REUTERS

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In its submission to regulators, Akeso included data on patient survival, disclosing that an interim analysis following 157 patient deaths found that participants on ivonescimab had a roughly 22% reduced risk of death, with a hazard ratio of 0.784, a company spokesperson confirmed to STAT. That finding is not statistically significant, but it does meet market analyst expectations, according to Wosen. In an email to STAT, an Akeso spokesperson noted that the interim analysis was not powered for statistical significance and that the company plans to conduct formal analyses of survival once 232 and 280 deaths have occurred in the trial. Shares of Summit Therapeutics fell 37% to $23.21 following the report before halting for news. BioNTech  dropped 17% to $100.06 in sympathy with Su","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"yahoofinance","url":"https://finance.yahoo.com/news/akeso-survival-data-ivonescimab-misses-165017764.html","rn_cache_url":null,"customStyle":"img, svg { display: none !important; 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Therapeutics closes 36% lower after interim data for cancer drug","url":"https://stock-news.laohu8.com/highlight/detail?id=2530919698","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2530919698?lang=en_us&edition=fundamental","pubTime":"2025-04-26 06:01","pubTimestamp":1745618508,"startTime":"0","endTime":"0","summary":"BUZZ-Summit Therapeutics closes 36% lower after interim data for cancer drug** Shares of Summit Therapeutics SMMT.O settle 36% lower to $23.47 at close, last up 3.81% to $24.36 in after-market trade** Co says in the submission for cancer drug ivonescimab in China by partner Akeso 9926.HK, the regulators asked for an interim analysis of overall survival** The drug was approved in China based on a trial that studied it against Merck's MRK.N Keytruda in patients with a type of lung cancer** The analysis showed a potential 22% reduced risk of death, with a hazard ratio of 0.777, which is not statistically significant, two analysts said** The simple fact that this still early cut is not statistically significant is triggering a massive sell-off - Evercore ISI** Summit said the interim analysis was conducted at 39% data maturity** Brokerage Truist expects overall survival benefit will reach statistical significance by the final analysis, if not potentially earlier** SMMT shares peaked in Sep","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250425:nL4N3R322S:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["LU2089984988.USD","IE00BJT1NW94.SGD","IE00BSNM7G36.USD","BK1161","LU2461242641.AUD","LU0203347892.USD","LU0058720904.USD","LU1699723380.USD","LU1934455277.USD","LU1974910355.USD","LU2112291526.USD","LU2324357040.USD","LU1093756168.USD","LU2468319806.SGD","BK4007","BK4559","LU0265550359.USD","EVR","LU1989772840.SGD","BK4516","LU1116320901.HKD","LU1989772923.USD","SMMT","LU1720050803.USD","IE0002141913.USD","SG9999001176.SGD","LU2361045086.USD","IE00B1BXHZ80.USD","LU0320765489.SGD","IE00B543WZ88.USD","LU1929549753.HKD","LU0122379950.USD","LU1037948541.HKD","LU2106854487.HKD","MRK","BK4585","LU0203345920.USD","LU0861579265.USD","LU1035773651.USD","SG9999014542.SGD","LU0234572021.USD","LU1066051498.USD","SGXZ57979304.SGD","BK4127","LU0211331839.USD","SG9999002224.SGD","LU0238689110.USD","LU0348783233.USD","LU1066051811.HKD"],"gpt_icon":1},{"id":"2530464193","title":"Summit Therapeutics Is Maintained at Buy by Jefferies","url":"https://stock-news.laohu8.com/highlight/detail?id=2530464193","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2530464193?lang=en_us&edition=fundamental","pubTime":"2025-04-26 05:17","pubTimestamp":1745615820,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/SMMT/analyst-ratings \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  April 25, 2025 17:17 ET (21:17 GMT)","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["LENZ","SMMT","SMMF"],"gpt_icon":0},{"id":"2530167481","title":"Summit Therapeutics Gets Approval From China's Health Authority for Second Use of Ivonescimab","url":"https://stock-news.laohu8.com/highlight/detail?id=2530167481","media":"MT Newswires Live","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2530167481?lang=en_us&edition=fundamental","pubTime":"2025-04-26 04:05","pubTimestamp":1745611532,"startTime":"0","endTime":"0","summary":"Summit Therapeutics  said Friday its partner Akeso has received approval from China's National Medical Products Administration for a second use of ivonescimab.The approval was based on results from a phase 3 clinical trial, called HARMONi-2, which tested ivonescimab alone against pembrolizumab alone in patients with advanced non-small cell lung cancer that shows PD-L1 protein, the company said.Following NMPA's instructions, Akeso conducted an interim analysis of overall survival and reported a hazard ratio of 0.777, based on 39% of the total data collected so far, it added.Summit is also running the HARMONi-7 trial, a global phase 3 study evaluating ivonescimab against pembrolizumab in a similar group of NSCLC patients for regulatory approval in the United States and other licensed regions, according to the company.Shares of the company were down nearly 32% in recent trading.Price: 23.42, Change: -13.29, Percent Change: -36.20","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"productRelease","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["LU2488822045.USD","BK4007","BK4139","SMMT","SMMF","LENZ","BK4211"],"gpt_icon":0},{"id":"2530416484","title":"Summit Therapeutics Shares Resume Trading After Halt, Last Down About 32% at Close to $25","url":"https://stock-news.laohu8.com/highlight/detail?id=2530416484","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2530416484?lang=en_us&edition=fundamental","pubTime":"2025-04-26 03:21","pubTimestamp":1745608866,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250425:nL1N3R312D:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4139","SMMT","LU2488822045.USD"],"gpt_icon":0},{"id":"2530316167","title":"Summit Therapeutics trading resumes","url":"https://stock-news.laohu8.com/highlight/detail?id=2530316167","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2530316167?lang=en_us&edition=fundamental","pubTime":"2025-04-26 03:20","pubTimestamp":1745608821,"startTime":"0","endTime":"0","summary":"15:20 EDT Summit Therapeutics (SMMT) trading resumes Published first on TheFly – the ultimate source for real-time, market-moving breaking financia...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/summit-therapeutics-trading-resumes-3?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/summit-therapeutics-trading-resumes-3?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["LU2488822045.USD","BK4007","BK4139","SMMT","SMMF","LENZ","BK4211"],"gpt_icon":0},{"id":"2530167390","title":"Summit Therapeutics to resume trading at 3:20 pm ET","url":"https://stock-news.laohu8.com/highlight/detail?id=2530167390","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2530167390?lang=en_us&edition=fundamental","pubTime":"2025-04-26 03:10","pubTimestamp":1745608220,"startTime":"0","endTime":"0","summary":"Summit Therapeutics (SMMT) shares are scheduled to resume trading at 3:20 pm ET, with quotes scheduled to resume at 3:15 pm ET, according to Nasdaq...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/summit-therapeutics-to-resume-trading-at-320-pm-et?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/summit-therapeutics-to-resume-trading-at-320-pm-et?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["TSYW.SI","BK4211","QID","BK4588","PSQ","BK4590","MNQmain",".IXIC","BK4581","SMMT","SMMF","USJW.SI","BK4585","BK4144","SQQQ","TQQQ","USAW.SI","BK4561","LU2488822045.USD","LENZ","QLD","BK4007","ET","NVIW.SI","NQmain","BK4139"],"gpt_icon":0},{"id":"2530692771","title":"Summit Therapeutics says new ivonescimab data clinically meaningful","url":"https://stock-news.laohu8.com/highlight/detail?id=2530692771","media":"TIPRANKS","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2530692771?lang=en_us&edition=fundamental","pubTime":"2025-04-26 02:55","pubTimestamp":1745607318,"startTime":"0","endTime":"0","summary":"Summit Therapeutics (SMMT) noted that Akeso (AKESF) announced ivonescimab was approved by the Chinese Health Authorities for a second indication ba...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/summit-therapeutics-says-new-ivonescimab-data-clinically-meaningful?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/summit-therapeutics-says-new-ivonescimab-data-clinically-meaningful?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["LENZ","BK4139","SMMT","AKESF","BK4211","LU2488822045.USD","SMMF","BK4007"],"gpt_icon":0},{"id":"2530165854","title":"Wells says Summit, Akeso data ‘not the bull case,’ but not ‘bear case either’","url":"https://stock-news.laohu8.com/highlight/detail?id=2530165854","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2530165854?lang=en_us&edition=fundamental","pubTime":"2025-04-26 01:55","pubTimestamp":1745603717,"startTime":"0","endTime":"0","summary":"Wells Fargo notes that Summit Therapeutics (SMMT) partner Akeso (AKESF) received approval from China’s NMPA for ivonescimab as a monotherapy for th...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/wells-says-summit-akeso-data-not-the-bull-case-but-not-bear-case-either?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/wells-says-summit-akeso-data-not-the-bull-case-but-not-bear-case-either?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["LU0310800965.SGD","LU0029864427.USD","LU0320765489.SGD","LU0128525689.USD","LU0417517546.SGD","LU1069347547.HKD","LU0310799852.SGD","LU0640476718.USD","LU1201861249.SGD","LU0130102774.USD","LU0314106906.USD","LU0211328371.USD","SMMT","IE00B7SZLL34.SGD","LU1267930227.SGD","LU2236285917.USD","LU2461242641.AUD","LU0211327993.USD","IE00B19Z3581.USD","LU0070302665.USD","BK4211","LU0477156953.USD","LU0208291251.USD","LU0256863811.USD","LU0128525929.USD","IE0002270589.USD","LU0130517989.USD","AKESF","LU1506573853.SGD","BK4588","LU0106831901.USD","LU0980610538.SGD","LU2361044949.HKD","LU0708994859.HKD","LU0072461881.USD","LU0048573561.USD","LU0251131958.USD","LU1791807156.HKD","LU1814569148.SGD","IE00B19Z3B42.SGD","BK4501","LU0787776722.HKD","LU0971096721.USD","LU0648001328.SGD","BK4207","SMMF","LU1267930573.SGD","LU0251142724.SGD","BK4585","LU0683600562.USD"],"gpt_icon":0},{"id":"2530520601","title":"Summit Therapeutics trading halted, news pending","url":"https://stock-news.laohu8.com/highlight/detail?id=2530520601","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2530520601?lang=en_us&edition=fundamental","pubTime":"2025-04-26 00:35","pubTimestamp":1745598917,"startTime":"0","endTime":"0","summary":"12:34 EDT Summit Therapeutics (SMMT) trading halted, news pending Published first on TheFly – the ultimate source for real-time, market-moving brea...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/summit-therapeutics-trading-halted-news-pending-3?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/summit-therapeutics-trading-halted-news-pending-3?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4139","SMMT","LU2488822045.USD","BK4211","BK4007","LENZ","SMMF"],"gpt_icon":0},{"id":"2530766131","title":"Summit Therapeutics Inc : Jefferies Raises Target Price to $44 From $31","url":"https://stock-news.laohu8.com/highlight/detail?id=2530766131","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2530766131?lang=en_us&edition=fundamental","pubTime":"2025-04-25 21:56","pubTimestamp":1745589369,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250425:nFWN3R323R:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["LU2488822045.USD","BK4139","SMMT"],"gpt_icon":0},{"id":"2530998750","title":"Summit Therapeutics to Host First Quarter 2025 Financial Results & Operational Progress Call on May 1, 2025","url":"https://stock-news.laohu8.com/highlight/detail?id=2530998750","media":"Business Wire","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2530998750?lang=en_us&edition=fundamental","pubTime":"2025-04-25 04:15","pubTimestamp":1745525700,"startTime":"0","endTime":"0","summary":"MIAMI, April 24, 2025----Summit Therapeutics Inc.   will host an earnings call to announce its first quarter 2025 financial results and provide an operational update for the Company on Thursday, May 1, 2025, after the market closes.Summit will host a live webcast of the earnings conference call at 4:30pm ET, which will be accessible through our website, www.smmttx.com. An archived edition of the session will be available on our website.Summit Therapeutics Inc. is a biopharmaceutical oncology company focused on the discovery, development, and commercialization of patient-, physician-, caregiver- and societal-friendly medicinal therapies intended to improve quality of life, increase potential duration of life, and resolve serious unmet medical needs.Summit was founded in 2003, and our shares are listed on the Nasdaq Global Market . We are headquartered in Miami, Florida, and we have additional offices in Menlo Park, California, and Oxford, UK.","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/summit-therapeutics-host-first-quarter-201500118.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["BK4588","BK4181","PRGS","BK4218","SMMF","SMMT","BK4211","BK4097","BK4007","BK4585","HST","LU2488822045.USD","BK4139","LENZ","LU2065732104.USD"],"gpt_icon":0},{"id":"2529864010","title":"Evercore ISI Remains a Buy on Summit Therapeutics (SMMT)","url":"https://stock-news.laohu8.com/highlight/detail?id=2529864010","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2529864010?lang=en_us&edition=fundamental","pubTime":"2025-04-24 14:38","pubTimestamp":1745476717,"startTime":"0","endTime":"0","summary":"Evercore ISI analyst Cory Kasimov reiterated a Buy rating on Summit Therapeutics (SMMT – Research Report) yesterday and set a price target of $30.0...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/evercore-isi-remains-a-buy-on-summit-therapeutics-smmt?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/evercore-isi-remains-a-buy-on-summit-therapeutics-smmt?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["LU2488822045.USD","SMMT","BK4139"],"gpt_icon":0},{"id":"2529266260","title":"Why Summit Therapeutics Inc. (SMMT) Went Up On Wednesday","url":"https://stock-news.laohu8.com/highlight/detail?id=2529266260","media":"Insider Monkey","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2529266260?lang=en_us&edition=fundamental","pubTime":"2025-04-24 06:13","pubTimestamp":1745446436,"startTime":"0","endTime":"0","summary":"Wall Street’s major indices rebounded anew on Wednesday as worries about tariff policies and the Federal Reserve’s independence tapered off after President Donald Trump assured that he had no intentions of ousting Jerome Powell.The Nasdaq surged by 2.5 percent, the S&P 500 rose by 1.67 percent, while the Dow Jones increased by 1.07 percent.Ten companies mirrored the broader market optimism as optimistic investors resumed pouring funds into their stocks. In this article, we have identified Wednesday’s 10 best-performing stocks during the intra-day trading and detailed the reasons behind their strong performance.To come up with the list, we considered only the stocks with more than $2 billion in market capitalization and $5 million in intraday trading volume.Summit Therapeutics surged by 23.76 percent at intra-day trading on Wednesday, a fourth straight day, before ending the day just up by 21.5 percent at $33.23 apiece as investor sentiment was boosted by the positive results of its pha","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/why-summit-therapeutics-inc-smmt-221356671.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["BK4139","SMMT","BK4195","LU2488822045.USD","PFS","BK4211"],"gpt_icon":0},{"id":"2529502798","title":"Summit Therapeutics Says Phase 3 Cell Lung Cancer Trial Met Primary Endpoint; Shares Rise Pre-Bell","url":"https://stock-news.laohu8.com/highlight/detail?id=2529502798","media":"MT Newswires Live","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2529502798?lang=en_us&edition=fundamental","pubTime":"2025-04-23 20:17","pubTimestamp":1745410673,"startTime":"0","endTime":"0","summary":"Summit Therapeutics  shares were higher premarket Wednesday after the company said that a phase 3 trial conducted by Akeso in China found that combining ivonescimab with chemotherapy demonstrated a clinically meaningful benefit compared with a tislelizumab-based regimen in patients with advanced squamous non-small cell lung cancer.The HARMONi-6 phase 3 study reached a primary endpoint of improving progression-free survival, based on an interim analysis by an independent committee, Summit said.The benefit was seen regardless of whether patients had PD-L1-positive or negative tumors, and no unexpected safety issues were observed, the company said.Summit also said this is the second late-stage trial in which an ivonescimab-based therapy has demonstrated a significant advantage over a PD-L1-based standard treatment.The company said it is running HARMONi-3, a phase 3 study comparing ivonescimab plus chemotherapy against pembrolizumab with chemotherapy for newly diagnosed metastatic patients","market":"sh","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"2","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["LENZ","SMMF","SMMT","BK4139","BK4007","BK4211","LU2488822045.USD"],"gpt_icon":0},{"id":"2529366502","title":"BUZZ-Summit Therapeutics gains as lung cancer drug succeeds in second study in China","url":"https://stock-news.laohu8.com/highlight/detail?id=2529366502","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2529366502?lang=en_us&edition=fundamental","pubTime":"2025-04-23 20:05","pubTimestamp":1745409947,"startTime":"0","endTime":"0","summary":"BUZZ-Summit Therapeutics gains as lung cancer drug succeeds in second study in China** Shares of Summit Therapeutics SMMT.O up 13.41% at $31.05 before the bell ** Company and partner Akeso's 9926.HK drug ivonescimab, in combination with chemotherapy, showed \"statistically significant superiority\" in progression-free survival for patients with a type of lung cancer ** The companies were testing ivonescimab-chemotherapy regime in a study conducted in China, against a tislelizumab, and chemotherapy combination ** Tislelizumab is sold as Tevimbra by BeiGene 688235.SS ** The companies plan to share detailed data from the study later this year and SMMT is currently enrolling patients in a multi-regional study for the drug ** SMMT shares peaked in September 2024 after results from a study in China showed some lung cancer patients on its experimental drug had better survival rates than those on Merck's MRK.N blockbuster Keytruda ** BMO analysts say the data \"further heats up competition\" in th","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250423:nL4N3R1168:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SG9999013999.USD","LU0203345920.USD","LU1941712264.USD","MRK","IE00B2B36J28.USD","LU0211331839.USD","LU1929549753.HKD","LU1989771016.USD","LU1934455277.USD","IE00BJT1NW94.SGD","LU1699723380.USD","IE0009355771.USD","LU0208291251.USD","SMMT","LU0238689110.USD","LU0266013472.USD","IE00BPRC5H50.USD","IE00B543WZ88.USD","IE00BBT3K403.USD","LU1974910355.USD","LU0265550359.USD","SG9999014575.USD","IE0002141913.USD","LU0265550946.USD","BK1161","LU1571399168.USD","LU0320765489.SGD","688235","LU2106854487.HKD","SG9999014559.SGD","BK4585","LU1023059063.AUD","LU2361045086.USD","LU0289739699.SGD","IE00BJJMRZ35.SGD","LU1162221912.USD","BK0239","LU2023250504.SGD","SG9999002224.SGD","LU1794554557.SGD","LU2089984988.USD","SG9999002232.USD","BK1574","LU2361044949.HKD","LU1585245621.USD","LU1066051225.USD","BK4533","LU0965509010.AUD","LU1057294990.SGD"],"gpt_icon":1},{"id":"2529150979","title":"S&P 500 Futures Rise In Premarket Trading; Pegasystems, Popular Inc. Lead","url":"https://stock-news.laohu8.com/highlight/detail?id=2529150979","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2529150979?lang=en_us&edition=fundamental","pubTime":"2025-04-23 19:30","pubTimestamp":1745407800,"startTime":"0","endTime":"0","summary":"This article was automatically generated by Barrons.com using technology from Automated Insights.With U.S. stock markets set to open in two hours, Pegasystems Inc.  was up 27.2% in pre-market trading, and Popular Inc.  was up 18.5%.Vertiv Holdings LLC , Webull Corp. Cl A , and Summit Therapeutics Inc.  were all posting gains of at least 9%. In early trading, Enphase Energy Inc.  and CCC Intelligent Solutions Holdings Inc.  had posted declines, falling 11.5% and 6.7%, respectively.Meanwhile S&P 500 futures were up 2.51%, with futures for the Dow Jones Industrial Average rising 1.86%. The Cboe Volatility Index futures were down 6.25%.In commodities news, Brent crude oil futures were up 0.76%, and gold futures were down 2.12%. Bitcoin climbed 2.43% to $93,781.In afternoon trading, stocks in Europe are up, with the STOXX Europe 600 Index rising 1.72% and the FTSE 100 Index rising 1.40% from the previous close.U.S. stock markets open for trading at 9:30 a.m. ET.Data source: Dow Jones Market","market":"other","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["LU0082616367.USD","LU1064131342.USD","LU0348723411.USD","LU1169589451.USD","IE00BN0W2W23.USD","PEGA","LU2488822045.USD","SPY","LU0823414478.USD","LU1548497426.USD","LU1988902786.USD","IE00BMPRXN33.USD","LU1983299162.USD","IE00BN0W2V16.EUR","LU2098885051.SGD","LU2249611893.SGD","BK4211","LU1720051108.HKD","LU1169590202.USD","SMMT","BK4585","IE00BMPRXR70.SGD","LU1093756325.SGD","BK4588","BK4127","BPOP","LU0823414551.USD","LU1720051017.SGD","LU1303367103.USD","VOO","ENPH","VRT","LU2294711713.HKD","IE00BN0W2T93.GBP","BK4096","LU1093756168.USD","IE00BMPRXQ63.HKD","BK4139","LU2506951792.HKD","BK4543","LU0719512351.SGD","BK4147","CCCS","LU2357125470.USD","LU2357305700.SGD","LU2264538146.SGD","LU2065731478.USD",".SPX","BK4023"],"gpt_icon":1},{"id":"2529067245","title":"Summit Therapeutics Rallies After Lung Cancer Drug Shows Positive Results","url":"https://stock-news.laohu8.com/highlight/detail?id=2529067245","media":"Dow Jones","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2529067245?lang=en_us&edition=fundamental","pubTime":"2025-04-23 19:17","pubTimestamp":1745407020,"startTime":"0","endTime":"0","summary":"Summit Therapeutics shares rallied after its lung cancer drug candidate showed that it improved patients' longevity without the disease worsening in a late-stage trial.Shares of Summit rose 11% to $30.41 premarket trading Thursday.The Miami biotech firm said its ivonescimab drug met the primary goal of progression-free survival when tested in combination with a platinum-based chemotherapy on patients with a certain type of non-small cell lung cancer.The Phase 3 clinical trial is being conducted in China in partnership with Chinese biotech firm Akeso to evaluate a combination of ivonescimab and platinum-based chemotherapy against tislelizumab combined with platinum-based chemotherapy in patients with locally advanced or metastatic squamous non-small cell lung cancer irrespective of PD-L1 expression.Patients taking the ivonescimab regimen saw a statistically significant and clinically meaningful improvement in progression-free survival compared to those taking the tislelizumab regimen, S","market":"sg","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"productRelease","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["LENZ","SMMT","LU2488822045.USD","SMMF","BK4007","BK4211","BK4139"],"gpt_icon":0},{"id":"2529774935","title":"Summit Therapeutics Shares up 11.4% 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