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Opthea Ltd

3.41

0.0000

Volume:- -

Turnover:- -

Market Cap:524.84M

PE:-1.62

High:3.41

Open:3.41

Low:3.41

Close:3.41

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Overview Company News Filings

Opthea Ends Development of Sozinibercept in Wet AMD

Opthea Terminates Sozinibercept Development After Failed Phase 3 Trials

MT Newswires Live

Opthea terminates COAST trial, announces ShORe trial misses endpoint

Opthea in active talks with funders after second trial fails

The Australian Financial Review

Opthea Announces Decision to Discontinue Wet AMD Trials

Opthea Halts Wet AMD Trials Following Unsuccessful Phase 3 Results

Scott Power: ASX health sector down in week of good and bad news

HotCopper Highlights for Week 13 – Opthea, Reject Shop, Bellevue & more!

The Market Herald

Why this sold-off ASX All Ords dividend stock is 'well placed to generate long-term shareholder value'

Closing Bell: Tech tumble and Trump tariffs trample Thursday

Pengana freezes fund redemptions as it braces for big Opthea loss

The Australian Financial Review

Analysts Offer Insights on Healthcare Companies: Opthea Limited (OtherCKDXF), Outset Medical (OM) and Maravai Lifesciences Holdings (MRVI)

HM1 Says Revaluation of Opthea's Holding Value to Negatively Impact NAV by 1.6%

MT Newswires Live

Opthea downgraded to Market Perform from Outperform at Leerink

Opthea cut to Market Perform at Leerink on failed sozinibercept trial

Opthea double downgraded to Underperform from Buy at Jefferies

Opthea downgraded to Neutral from Buy at H.C. Wainwright

Trading in Opthea Still Halted After Phase 3 Study Failure

Opthea Cut to Market Perform From Outperform by Leerink Partners

Opthea Cut to Neutral From Buy by HC Wainwright & Co.

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Ends Development of Sozinibercept in Wet AMD","url":"https://stock-news.laohu8.com/highlight/detail?id=2523420469","media":"Dow Jones","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2523420469?lang=en_us&edition=fundamental","pubTime":"2025-03-31 21:37","pubTimestamp":1743428220,"startTime":"0","endTime":"0","summary":"Opthea is scrapping development of lead product candidate sozinibercept in wet age-related macular degeneration, or wet AMD, following the failure of another late-stage study.Opthea on Monday said its second Phase 3 study of sozinibercept in combination with aflibercept in wet AMD, an eye condition that causes blurred vision or reduced central vision, missed its primary endpoint of mean change in best corrected visual acuity.The clinical-stage biopharmaceutical company said it opted to accelerate the study readout following the similar Phase 3 study failure it reported last week.Opthea said it agreed with the investors in its development funding agreement to end development of sozinibercept in wet AMD, and that the move wouldn't constitute a termination event under the funding deal.However, the company warned once again that it might be required to pay amounts to the investors--which would have a material adverse effect on its solvency--and that there is material uncertainty about its 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Terminates Sozinibercept Development After Failed Phase 3 Trials","url":"https://stock-news.laohu8.com/highlight/detail?id=2523956912","media":"MT Newswires Live","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2523956912?lang=en_us&edition=fundamental","pubTime":"2025-03-31 18:58","pubTimestamp":1743418697,"startTime":"0","endTime":"0","summary":"Opthea  said Monday that a phase 3 trial evaluating the efficacy and safety of 2 mg sozinibercept for wet age-related macular degeneration failed to meet its primary endpoint of improved visual acuity.The announcement is the second blow for the company as another phase 3 failed to meet its primary goal last week.Opthea and its Development Funding Agreement investors have agreed to immediately discontinue the development of sozinibercept for wet age-related macular degeneration, the company said.It added that the decision does not trigger a termination event under the  Development Funding Agreement, meaning no payment is required to be made by Opthea.The company said it continues discussions with  Development Funding Agreement investors to explore potential options for its future.Opthea estimates it will have $100 million in cash and cash equivalents by the end of March 2025 but faces uncertainty about its ability to continue as a going concern, the drug developer said.The ASX will susp","market":"sg","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"productRelease","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["OPT","OPT.AU","BK7067","BK4139","BK7508"],"gpt_icon":0},{"id":"2523916040","title":"Opthea terminates COAST trial, announces ShORe trial misses endpoint","url":"https://stock-news.laohu8.com/highlight/detail?id=2523916040","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2523916040?lang=en_us&edition=fundamental","pubTime":"2025-03-31 17:45","pubTimestamp":1743414319,"startTime":"0","endTime":"0","summary":"Opthea (OPT) announced updates on its Phase 3 clinical program, including the termination of COAST and accelerated topline results from its second ...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/opthea-terminates-coast-trial-announces-shore-trial-misses-endpoint?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/opthea-terminates-coast-trial-announces-shore-trial-misses-endpoint?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["OPT","BK4139"],"gpt_icon":0},{"id":"2523564962","title":"Opthea in active talks with funders after second trial fails","url":"https://stock-news.laohu8.com/highlight/detail?id=2523564962","media":"The Australian Financial Review","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2523564962?lang=en_us&edition=fundamental","pubTime":"2025-03-31 14:52","pubTimestamp":1743403920,"startTime":"0","endTime":"0","summary":"ASX-listed biotech Opthea says it has terminated the second of its two trials of drugs to treat a common eye disease, delivering a near mortal blow to shareholders who had already written down the majority of their investments.The company said on Monday that a second phase 3 trial “did not meet its primary endpoint” after disappointing investors only last week with the news that a first phase 3 trial had failed.Loading...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.afr.com/markets/equity-markets/opthea-in-active-talks-with-funders-after-second-trial-fails-20250331-p5lnx7","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"afr_stock","symbols":["OPT"],"gpt_icon":0},{"id":"2523951735","title":"Opthea Announces Decision to Discontinue Wet AMD Trials","url":"https://stock-news.laohu8.com/highlight/detail?id=2523951735","media":"GlobeNewswire","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2523951735?lang=en_us&edition=fundamental","pubTime":"2025-03-31 12:01","pubTimestamp":1743393660,"startTime":"0","endTime":"0","summary":"ShORe Phase 3 topline results accelerated; trial did not meet primary endpoint of mean change in BCVA from baseline to week 52. Opthea and DFA Investors agreed to terminate both COAST and ShORe trials. Opthea continues to consider impact of negative trial results under its Development Funding Agreement  and on the Company as a going concern. The global ShORe Phase 3 trial evaluated the efficacy and safety of intravitreally administered 2 mg sozinibercept every four or eight weeks in combination with 0.5 mg ranibizumab every four weeks, as per label, versus 0.5 mg ranibizumab monotherapy. The trial did not meet its primary endpoint of mean change in best corrected visual acuity  from baseline to week 52.“We are disappointed that COAST and ShORe did not demonstrate the improvements in vision with sozinibercept combination therapy compared to standard of care that we had hoped for,” said Frederic Guerard, PharmD, Chief Executive Officer of Opthea. “We are grateful to all patients, clinica","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/opthea-announces-decision-discontinue-wet-040100489.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["LU0082616367.USD","LU1951200564.SGD","LU2360106780.USD","BK4575","LU1880398471.USD","LU1316542783.SGD","LU1988902786.USD","BK4605","LU0823434740.USD","BK4512","BK4554","LU0390134368.USD","IE0004445239.USD","LU0642271901.SGD","LU2250418816.HKD","BK4573","LU2054465674.USD","BK4529","LU0979878070.USD","BK4614","BK4534","LU2458330169.SGD","IE00BMPRXR70.SGD","LU2098885051.SGD","LU0719512351.SGD","BK4585","LU0823421416.USD","OPT.AU","LU1989764664.SGD","GFS","LU0823434583.USD","LU0081259029.USD","BK4139","LU1242518857.USD","LU0127658192.USD","BK4566","IE00BMPRXN33.USD","LU1951198990.SGD","IE00B5949003.HKD","LU0889565833.HKD","LU1852331112.SGD","BK4141","LU1880398554.USD","LU1803068979.SGD","LU1923623000.USD","BK4612","LU1303367103.USD","LU2264538146.SGD","OPT","LU1064131342.USD"],"gpt_icon":1},{"id":"2523956241","title":"Opthea Halts Wet AMD Trials Following Unsuccessful Phase 3 Results","url":"https://stock-news.laohu8.com/highlight/detail?id=2523956241","media":"TIPRANKS","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2523956241?lang=en_us&edition=fundamental","pubTime":"2025-03-31 11:18","pubTimestamp":1743391097,"startTime":"0","endTime":"0","summary":"An announcement from Opthea Limited ( ($AU:OPT) ) is now available. Opthea Limited has announced the discontinuation of its Phase 3 trials, COAST a...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/company-announcements/opthea-halts-wet-amd-trials-following-unsuccessful-phase-3-results?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/company-announcements/opthea-halts-wet-amd-trials-following-unsuccessful-phase-3-results?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["LU0889565833.HKD","LU1242518857.USD","LU2054465674.USD","LU0081259029.USD","LU1989764664.SGD","IE00BMPRXN33.USD","LU2264538146.SGD","LU1242518931.SGD","LU1880398554.USD","LU0390134368.USD","LU2458330169.SGD","LU1803068979.SGD","BK4534","BK4529","GFS","BK4139","BK4612","BK4588","LU1316542783.SGD","LU2360106780.USD","BK4566","LU0056508442.USD","BK4605","LU0082616367.USD","LU0979878070.USD","IE00B5949003.HKD","IE0009356076.USD","LU0823421416.USD","BK4554","BK4141","LU0823421333.USD","LU1852331112.SGD","LU1064131342.USD","BK4573","LU1303367103.USD","BK4512","LU2458330243.SGD","LU0719512351.SGD","BK4614","BK4532","IE00BMPRXR70.SGD","LU0642271901.SGD","LU2250418816.HKD","LU0823434583.USD","LU2098885051.SGD","LU0823434740.USD","OPT","LU1880398471.USD","LU1988902786.USD"],"gpt_icon":0},{"id":"2522512071","title":"Scott Power: ASX health sector down in week of good and bad news","url":"https://stock-news.laohu8.com/highlight/detail?id=2522512071","media":"Stockheads","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2522512071?lang=en_us&edition=fundamental","pubTime":"2025-03-28 14:14","pubTimestamp":1743142455,"startTime":"0","endTime":"0","summary":"ASX heath sector falls 2.1%, while broader markets rise 0.8% for the same period. Opthea phase III Coast trial into wet AMD fails to meet primary and secondary endpoints. EMVision starts pivotal validation trial for emu bedside brain scanner to diagnose stroke","market":"nz","thumbnail":"https://stockhead.com.au/wp-content/uploads/2025/03/GettyImages-108225711-1200x675-1-640x360.jpg","type":0,"news_type":0,"thumbnails":["https://stockhead.com.au/wp-content/uploads/2025/03/GettyImages-108225711-1200x675-1-640x360.jpg"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://stockhead.com.au/health/scott-power-asx-health-sector-down-in-week-of-good-and-bad-news/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"stockheads_stock","symbols":["PW","BK4213","TMC","ASA","OPT","BK4168","BK4563","BK4139","SOC","DHS","BK4084","BK4234"],"gpt_icon":0},{"id":"2522058513","title":"HotCopper Highlights for Week 13 – Opthea, Reject Shop, Bellevue & more!","url":"https://stock-news.laohu8.com/highlight/detail?id=2522058513","media":"The Market Herald","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2522058513?lang=en_us&edition=fundamental","pubTime":"2025-03-28 14:14","pubTimestamp":1743142440,"startTime":"0","endTime":"0","summary":"Good Afternoon and welcome to HotCopper Highlights, I’m Jonathon Davidson. This is where we highlight what you were watching and discussing most on the forums this week. Let’s get into it.Opthea Limitedattracted much attention this week after its Phase 3 trial results treating age-related vision loss came up empty handed – which is to say its flagship drug doesn’t work.This is the biotech equivalent of a gas company drilling a duster, and sentiment went about how you’d expect. Opthea is now in crisis talks with investors to figure out whether it should keep going, or just give up. Talk about a bummer.Meanwhile, Australian dollar storethe Reject Shoprocketed this week as a surprise buyout offer from a Canadian value retailer giant called Dollarama valued shares at nearly $6.70 cents each, which a price the Reject Shop has struggled to return to since February 2022.That’s HotCopper Highlights for this week, I’m Jonathon Davidson, have a great weekend and we’ll see you on Monday.","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://themarketonline.com.au/hotcopper-highlights-for-week-13-opthea-reject-shop-bellevue-more-2025-03-28/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"markerherald_stock","symbols":["OPT"],"gpt_icon":0},{"id":"2522532974","title":"Why this sold-off ASX All Ords dividend stock is 'well placed to generate long-term shareholder value'","url":"https://stock-news.laohu8.com/highlight/detail?id=2522532974","media":"MotleyFool","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2522532974?lang=en_us&edition=fundamental","pubTime":"2025-03-28 04:30","pubTimestamp":1743107400,"startTime":"0","endTime":"0","summary":"ASX All Ords dividend stock Regal Partners Ltd  is having a wild ride this week. Shares in the All Ordinaries Index  listed alternative investment manager closed down 8.85% on Thursday at $2.37. That followed on a gain of 2.4% on Wednesday and a gain of 5.4% on Tuesday. All of which followed a painful 14.8% decline on Monday. Why the big fall in Regal Partners shares on Monday?Monday's big sell-off in the ASX All Ords dividend stock followed on concerning news from eye treatment company Opthea Limited . Opthea reported that its phase 3 COAST clinical trial had failed to meet its primary goal. And as the Motley Fool's Bronwyn Allen noted, \"The failure of the trial raises serious financial concerns for Opthea.\" Indeed, Opthea stated, \"In light of these matters, there remains material uncertainty as to Opthea's ability to continue as a going concern.\" So, why were investors selling Regal Partners shares on the news?","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.fool.com.au/2025/03/28/why-this-sold-off-asx-all-ords-dividend-stock-is-well-placed-to-generate-long-term-shareholder-value/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"motleyfoolau_stock","symbols":["BK7062","RPL.AU","BK7508","BK4139","BK7067","OPT.AU","XAO.AU","OPT"],"gpt_icon":0},{"id":"2522775321","title":"Closing Bell: Tech tumble and Trump tariffs trample Thursday","url":"https://stock-news.laohu8.com/highlight/detail?id=2522775321","media":"Stockheads","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2522775321?lang=en_us&edition=fundamental","pubTime":"2025-03-27 15:37","pubTimestamp":1743061048,"startTime":"0","endTime":"0","summary":"Despite a late upturn, the ASX 200 closed 0.38% in the red on Thursday. Blame factor 2: A Wall Street tech rout, which Trump had a hand in, too. to quickly recap, tech stocks took a pounding today on the back of a Wall Street dump across the sector, with AI behemoth Nvidia leading losses with a 6% stumble.According to reports, fears around the company’s business in China sent investors into a bit of a tizz, after the White House added several Chinese companies to a trade blacklist.Per a report in The Australian:The US has added dozens of Chinese companies to a trade blacklist over national security concerns. American businesses seeking to sell technology to these companies will need approval from the government.One of those companies blacklisted is Inspur Group – China’s largest server maker and one of the key Chinese customers of Nvidia.The Trump effect didn’t end there, his newly announced 25% US auto import tariffs  also wrought havoc on global markets, with Tesla, among other carma","market":"nz","thumbnail":"https://stockhead.com.au/wp-content/uploads/2025/03/GettyImages-128501522-1200x675-1-640x360.jpg","type":0,"news_type":0,"thumbnails":["https://stockhead.com.au/wp-content/uploads/2025/03/GettyImages-128501522-1200x675-1-640x360.jpg"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://stockhead.com.au/news/closing-bell-tech-tumble-and-trump-tariffs-trample-thursday/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"stockheads_stock","symbols":["ALD","BK4139","OPT"],"gpt_icon":0},{"id":"2522636206","title":"Pengana freezes fund redemptions as it braces for big Opthea loss","url":"https://stock-news.laohu8.com/highlight/detail?id=2522636206","media":"The Australian Financial Review","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2522636206?lang=en_us&edition=fundamental","pubTime":"2025-03-27 08:55","pubTimestamp":1743036900,"startTime":"0","endTime":"0","summary":"The failure of Opthea’s much-heralded eye treatment has already caused considerable pain for investors. The ASX-listed biotech counted Phil King’s Regal Partners as its biggest shareholder, with a 30 ","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.afr.com/street-talk/pengana-freezes-fund-redemptions-as-it-braces-for-big-opthea-loss-20250327-p5lmym","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"afr_stock","symbols":["OPT","BK4139"],"gpt_icon":0},{"id":"2522863812","title":"Analysts Offer Insights on Healthcare Companies: Opthea Limited (OtherCKDXF), Outset Medical (OM) and Maravai Lifesciences Holdings (MRVI)","url":"https://stock-news.laohu8.com/highlight/detail?id=2522863812","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2522863812?lang=en_us&edition=fundamental","pubTime":"2025-03-26 10:10","pubTimestamp":1742955012,"startTime":"0","endTime":"0","summary":"Companies in the Healthcare sector have received a lot of coverage today as analysts weigh in on Opthea Limited (CKDXF – Research Report), Outset M...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/analysts-offer-insights-on-healthcare-companies-opthea-limited-otherckdxf-outset-medical-om-and-maravai-lifesciences-holdings-mrvi?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/analysts-offer-insights-on-healthcare-companies-opthea-limited-otherckdxf-outset-medical-om-and-maravai-lifesciences-holdings-mrvi?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4137","CKDXF","OM","HCSG","OPT","BK4082","BK4139","BK4121","MRVI"],"gpt_icon":0},{"id":"2522083015","title":"HM1 Says Revaluation of Opthea's Holding Value to Negatively Impact NAV by 1.6%","url":"https://stock-news.laohu8.com/highlight/detail?id=2522083015","media":"MT Newswires Live","labels":["shareholding"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2522083015?lang=en_us&edition=fundamental","pubTime":"2025-03-26 07:49","pubTimestamp":1742946561,"startTime":"0","endTime":"0","summary":"Hearts and Minds Investments  said its revaluation of the holding value of Opthea  in its portfolio to AU$0.20 per share, will negatively impact its net asset value by about 1.6% or AU$0.056 per share, according to a Wednesday filing with the Australian bourse.The revaluation takes into account the study results, as well as the potential for a \"positive outcome\" from the upcoming trial readout.The company confirmed that it held a 2.4% stake in Opthea prior to the biopharmaceutical company's results of its study, the filing said.Opthea said Monday that its Combination OPT-302 with Aflibercept  study in patients with age-related Macular Degeneration, failed to meet its primary endpoint and added there is significant doubt about its ability to continue as a going concern.Shares of the company rose 1% in recent Wednesday trade.Price : $3.05, Change: $+0.040, Percent Change: +1.33%","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"shareholding","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["OPT","NAV","BK4139","BK7067","OPT.AU","BK7508","HM1.AU"],"gpt_icon":0},{"id":"2522884743","title":"Opthea downgraded to Market Perform from Outperform at Leerink","url":"https://stock-news.laohu8.com/highlight/detail?id=2522884743","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2522884743?lang=en_us&edition=fundamental","pubTime":"2025-03-26 03:20","pubTimestamp":1742930410,"startTime":"0","endTime":"0","summary":"Leerink analyst Marc Goodman downgraded Opthea (OPT) to Market Perform from Outperform. Published first on TheFly – the ultimate source for real-ti...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/opthea-downgraded-to-market-perform-from-outperform-at-leerink?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/opthea-downgraded-to-market-perform-from-outperform-at-leerink?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["OPT"],"gpt_icon":0},{"id":"2522088476","title":"Opthea cut to Market Perform at Leerink on failed sozinibercept trial","url":"https://stock-news.laohu8.com/highlight/detail?id=2522088476","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2522088476?lang=en_us&edition=fundamental","pubTime":"2025-03-26 03:19","pubTimestamp":1742930387,"startTime":"0","endTime":"0","summary":"Leerink downgraded Opthea (OPT) to Market Perform from Outperform with a price target of $1, down from $12. The firm cites the company announcing t...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/opthea-cut-to-market-perform-at-leerink-on-failed-sozinibercept-trial?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/opthea-cut-to-market-perform-at-leerink-on-failed-sozinibercept-trial?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4139","OPT"],"gpt_icon":0},{"id":"2522988477","title":"Opthea double downgraded to Underperform from Buy at Jefferies","url":"https://stock-news.laohu8.com/highlight/detail?id=2522988477","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2522988477?lang=en_us&edition=fundamental","pubTime":"2025-03-26 03:16","pubTimestamp":1742930211,"startTime":"0","endTime":"0","summary":"Jefferies double downgraded Opthea (OPT) to Underperform from Buy with a price target of $1, down from $8, after the company announced that its Eyl...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/opthea-double-downgraded-to-underperform-from-buy-at-jefferies?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/opthea-double-downgraded-to-underperform-from-buy-at-jefferies?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["OPT"],"gpt_icon":0},{"id":"2522889027","title":"Opthea downgraded to Neutral from Buy at H.C. Wainwright","url":"https://stock-news.laohu8.com/highlight/detail?id=2522889027","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2522889027?lang=en_us&edition=fundamental","pubTime":"2025-03-26 02:36","pubTimestamp":1742927792,"startTime":"0","endTime":"0","summary":"H.C. Wainwright analyst Matthew Caufield downgraded Opthea (OPT) to Neutral from Buy with a price target of $2, down from $12 after the Phase 3 COA...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/opthea-downgraded-to-neutral-from-buy-at-h-c-wainwright?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/opthea-downgraded-to-neutral-from-buy-at-h-c-wainwright?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["OPT"],"gpt_icon":0},{"id":"2522072540","title":"Trading in Opthea Still Halted After Phase 3 Study Failure","url":"https://stock-news.laohu8.com/highlight/detail?id=2522072540","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2522072540?lang=en_us&edition=fundamental","pubTime":"2025-03-26 00:43","pubTimestamp":1742920980,"startTime":"0","endTime":"0","summary":"Trading in shares of Opthea remains halted in the U.S. and Australia after the clinical-stage biopharmaceutical company said its lead product candidate, sozinibercept, failed in a late-stage study in wet age-related macular degeneration, or wet AMD.Opthea on Monday said the Phase 3 study of sozinibercept in combination with aflibercept in wet AMD, an eye condition that causes blurred vision or reduced central vision, missed its primary endpoint of mean change in best corrected visual acuity.Opthea said it is considering the impact of the negative study results under its development funding agreement, adding that it may be required to pay amounts to the investors that would have a material adverse impact on its solvency, and that there is material uncertainty about its ability to continue as a going concern.The company said it is in talks with its development funding investors to determine the most appropriate course of action, and that it has requested that trading in its securities 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25, 2025 08:59 ET (12:59 GMT)","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["OPT"],"gpt_icon":0}],"pageSize":20,"totalPage":8,"pageCount":2,"totalSize":152,"code":"91000000","status":"200"}],"@#url:\"https://hq.skytigris.cn/fundamental/corporate_actions/details/OPT\",params:#limit:5,,,undefined,":[{"date":"2025-04-29","symbol":"OPT","type":"earning","reportTimeType":"post","market":"US","fiscalQuarterEnding":null,"expectedEps":null,"defaultRemindTime":1745956800000,"name":null,"time":"Post 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