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Leap Therapeutics Inc

0.4060

+0.03559.58%

Volume:571.14K

Turnover:223.82K

Market Cap:16.75M

PE:-0.24

High:0.4147

Open:0.3599

Low:0.3570

Close:0.3705

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Overview Company News Filings

Leap Therapeutics Inc reports results for the quarter ended March 31 - Earnings Summary

BRIEF-Leap Therapeutics Q1 Net Income USD -15.435 Million

BRIEF-Leap Therapeutics - Announces 50% Workforce Reduction In Strategic Restructuring - SEC Filing

Leap Therapeutics Inc - Announces 50% Workforce Reduction in Strategic Restructuring - SEC Filing

THOMSON REUTERS

Leap Therapeutics - Q1 Loss per Share $0.37

THOMSON REUTERS

Leap Therapeutics Reports Q1 2025 Net Loss of $15.4M, Up from $13.8M in Q1 2024, Due to Increased R&D Expenses

Leap Therapeutics Q1 EPS USD -0.37

THOMSON REUTERS

Leap Therapeutics Inc: Has Reduced Its Workforce by Approximately 50%

THOMSON REUTERS

Leap Therapeutics Inc: Strategic Restructuring to Prioritize Clinical Focus on Development of Sirexatamab in Crc

THOMSON REUTERS

Leap Therapeutics Q1 Operating Expenses USD 15.917 Million

THOMSON REUTERS

Leap Therapeutics Inc expected to post a loss of 38 cents a share - Earnings Preview

Leap Therapeutics to Present Preclinical Data of FL-501, a Novel GDF-15 Neutralizing Antibody, at the AACR 2025 Annual Meeting

Leap Therapeutics to Host Virtual KOL Event to Discuss Sirexatamab (DKN-01) in Second-line Patients with Advanced Microsatellite Stable Colorectal Cancer

Penny Stock Leap Therapeutics Unveils Positive Data From Experimental Combo Therapy For Colorectal Cancer

Leap Therapeutics Says New Data Show Sirexatamab Improves Survival in Colorectal Cancer Trial

MT Newswires Live

BRIEF-Leap Therapeutics Reports Fourth Quarter And FY 2024 Results

Leap Therapeutics Q4 Operating Expenses USD 16.125 Million

THOMSON REUTERS

Leap Therapeutics Reports Fourth Quarter and Full Year 2024 Financial Results

Leap Therapeutics Reports Positive Updated Data From Sirexatamab Colorectal Cancer Study

THOMSON REUTERS

Leap Therapeutics Reports Positive Updated Data from Sirexatamab Colorectal Cancer Study

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The rise in net loss was primarily attributed to increased research and development expenses, which were $12.9 million compared to $11.3 million for the same period in 2024. This increase was mainly due to higher clinical trial costs associated with the expansion of Part B of the DeFianCe study and increased activity related to the end of Part C of the DisTinGuish study. General and administrative expenses decreased to $3.0 million from $3.5 million in the previous year, owing to reductions in professional fees and stock-based compensation expenses. Leap Therapeutics reported cash and cash equivalents totaling $32.7 million as of March 31, 2025. The company also highlighted positive data from their Phase 2 DeFianCe study of sirexatamab in colorectal cancer patients, showing significant","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250513:nNDLb8wTQ8:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["LPTX","BK4505","BK4563","BK4139"],"gpt_icon":0},{"id":"2535726803","title":"Leap Therapeutics Q1 EPS USD -0.37","url":"https://stock-news.laohu8.com/highlight/detail?id=2535726803","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2535726803?lang=en_us&edition=fundamental","pubTime":"2025-05-13 19:00","pubTimestamp":1747134009,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250513:nPLX0E511B:4","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4563","BK4505","BK4139","LPTX"],"gpt_icon":0},{"id":"2535726034","title":"Leap Therapeutics Inc: Has Reduced Its Workforce by Approximately 50%","url":"https://stock-news.laohu8.com/highlight/detail?id=2535726034","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2535726034?lang=en_us&edition=fundamental","pubTime":"2025-05-13 19:00","pubTimestamp":1747134009,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250513:nPLX0E511B:5","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["LPTX","BK4505","BK4563","BK4139"],"gpt_icon":0},{"id":"2535260327","title":"Leap Therapeutics Inc: Strategic Restructuring to Prioritize Clinical Focus on Development of Sirexatamab in Crc","url":"https://stock-news.laohu8.com/highlight/detail?id=2535260327","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2535260327?lang=en_us&edition=fundamental","pubTime":"2025-05-13 19:00","pubTimestamp":1747134009,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250513:nPLX0E511B:6","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4139","BK4563","BK4505","LPTX"],"gpt_icon":0},{"id":"2535237677","title":"Leap Therapeutics Q1 Operating Expenses USD 15.917 Million","url":"https://stock-news.laohu8.com/highlight/detail?id=2535237677","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2535237677?lang=en_us&edition=fundamental","pubTime":"2025-05-13 19:00","pubTimestamp":1747134009,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250513:nPLX0E511B:3","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4139","BK4505","BK4563","LPTX"],"gpt_icon":0},{"id":"2534345224","title":"Leap Therapeutics Inc  expected to post a loss of 38 cents a share - Earnings Preview","url":"https://stock-news.laohu8.com/highlight/detail?id=2534345224","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2534345224?lang=en_us&edition=fundamental","pubTime":"2025-05-09 23:28","pubTimestamp":1746804498,"startTime":"0","endTime":"0","summary":"Leap Therapeutics Inc  expected to post a loss of38cents a share - Earnings Preview Leap Therapeutics Inc LPTX.OQ LPTX.O is expected to show no change in quarterly revenue when it reports  results on ","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["earning"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250509:nL8N3RH2HV:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["LPTX"],"gpt_icon":0},{"id":"2530165377","title":"Leap Therapeutics to Present Preclinical Data of FL-501, a Novel GDF-15 Neutralizing Antibody, at the AACR 2025 Annual Meeting","url":"https://stock-news.laohu8.com/highlight/detail?id=2530165377","media":"PR Newswire","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2530165377?lang=en_us&edition=fundamental","pubTime":"2025-04-26 01:00","pubTimestamp":1745600400,"startTime":"0","endTime":"0","summary":"FL-501 fully restored body composition and reversed key indicators of cachexia in preclinical models. Findings confirm GDF-15's role in cachexia and support advancing FL-501 into the clinic. FL-501 is a potential best-in-class monoclonal antibody targeting growth differentiation factor 15 , a cytokine that is implicated in multiple diseases and therapeutic areas, including cancer cachexia.\"Cancer cachexia is a devasting and potentially life-threatening condition characterized by significant weight loss, muscle wasting, fatigue, and severely reduced quality of life. It is a major contributor to cancer-related mortality, and unfortunately there are no effective treatment options available to patients,\" said Jason Baum, PhD, Chief Scientific Officer of Leap. \"These data not only demonstrate that FL-501 is a novel and potential best-in-class anti-GDF-15 antibody, but also capable of fully restoring body composition in preclinical models that is comparable or better than other, clinical-sta","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"yahoofinance","url":"https://finance.yahoo.com/news/leap-therapeutics-present-preclinical-data-170000937.html","rn_cache_url":null,"customStyle":"img, svg { display: none !important; }","selectors":"article","filters":"","directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/leap-therapeutics-present-preclinical-data-170000937.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["FL","LPTX","LENZ"],"gpt_icon":0},{"id":"2527492277","title":"Leap Therapeutics to Host Virtual KOL Event to Discuss Sirexatamab (DKN-01) in Second-line Patients with Advanced Microsatellite Stable Colorectal Cancer","url":"https://stock-news.laohu8.com/highlight/detail?id=2527492277","media":"PR Newswire","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2527492277?lang=en_us&edition=fundamental","pubTime":"2025-04-15 19:00","pubTimestamp":1744714800,"startTime":"0","endTime":"0","summary":"Virtual KOL Event on Wednesday, April 23, 2025, at 2:30 p.m. ET. CAMBRIDGE, Mass., April 15, 2025 /PRNewswire/ --Leap Therapeutics, Inc. , a biotechnology company focused on developing targeted and immuno-oncology therapeutics, today announced it will host a virtual key opinion leader  event featuring Zev A. Wainberg, MD, Professor of Medicine at University of California, Los Angeles  and co-director of the UCLA GI Oncology Program, on Wednesday, April 23, 2025 at 2:30 p.m. ET. To register, please click here.Dr. Wainberg will connect with Leap's Chief Medical Officer, Cynthia Sirard, MD, to discuss the unmet need and how sirexatamab  may improve upon the current treatment landscape for previously treated patients with advanced microsatellite stable  colorectal cancer .The event will focus on reviewing the positive data from Part B of the Phase 2 DeFianCe study of sirexatamab in second-line patients with advanced MSS CRC. Sirexatamab, Leap's most advanced clinical program, is a humanize","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"yahoofinance","url":"https://finance.yahoo.com/news/leap-therapeutics-host-virtual-kol-110000836.html","rn_cache_url":null,"customStyle":"img, svg { display: none !important; }","selectors":"article","filters":"","directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/leap-therapeutics-host-virtual-kol-110000836.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["CRC","HST","LPTX","LU0266512127.USD","BK4563","IE00B19Z4B17.USD","LENZ","KOL","IE0031619046.USD","IE00B7SZL793.SGD","BK4181","IE00B66KJ199.SGD","BK4588","AEIS","BK4213","LU0456854461.SGD","BK4157","BK4218","BK4113","BK4007","BK4139","MSS","BK4585","BK4505"],"gpt_icon":0},{"id":"2522455332","title":"Penny Stock Leap Therapeutics Unveils Positive Data From Experimental Combo Therapy For Colorectal Cancer","url":"https://stock-news.laohu8.com/highlight/detail?id=2522455332","media":"Benzinga","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2522455332?lang=en_us&edition=fundamental","pubTime":"2025-03-27 01:29","pubTimestamp":1743010151,"startTime":"0","endTime":"0","summary":"Leap Therapeutics, Inc. presented updated preliminary data on Wednesday from Part B of the DeFianCe Phase 2 trial of sirexatamab  in combination with bevacizumab and chemotherapy  compared to bevacizumab and chemotherapy .The trial enrolled patients with advanced microsatellite stable  colorectal cancer  who have received one prior systemic therapy for advanced disease.The updated analysis shared on Wednesday includes the overall response rate , an additional two months of patient follow-up for progression-free survival , and initial overall survival  data.As ofMarch 12, 2025, 34 patients remain on the study drug in the sirexatamab Experimental Arm compared to 24 patients in the Control Arm.In patients with highDKK1levels, the sirexatamab Experimental Arm has a statistically significant 32% higher ORR, 3.5 months longer PFS, and OS compared to the Control Arm:. In patients who had not received prior anti-VEGF therapy, the sirexatamab Experimental Arm has a statistically significant 22%","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/penny-stock-leap-therapeutics-unveils-172911695.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["BK4113","IE00BMPRXQ63.HKD","MSS","BK4588","BK4211","LPTX","IE00BMPRXN33.USD","BK4505","OS","BK4139","PFS","BK4609","BK4141","ORR","ONC","BK4563","LU0348723411.USD","LU0266512127.USD","BK4195","BK4585","LU0456854461.SGD","BK4213","BK4097","CRC","IE00BMPRXR70.SGD","LENZ","BK4543"],"gpt_icon":1},{"id":"2522810870","title":"Leap Therapeutics Says New Data Show Sirexatamab Improves Survival in Colorectal Cancer Trial","url":"https://stock-news.laohu8.com/highlight/detail?id=2522810870","media":"MT Newswires Live","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2522810870?lang=en_us&edition=fundamental","pubTime":"2025-03-26 20:31","pubTimestamp":1742992311,"startTime":"0","endTime":"0","summary":"Leap Therapeutics  said Wednesday that updated findings from its phase 2 trial indicate that sirexatamab combined with bevacizumab and chemotherapy improves progression-free survival and overall response rate in patients with advanced colorectal cancer.Leap reported that patients with elevated DKK1 protein levels who were treated with sirexatamab in addition to bevacizumab and chemotherapy had a 32% higher overall response rate and lived 3.5 months longer without their cancer worsening compared with patients receiving only bevacizumab and chemotherapy.The company also said that patients who had not previously received anti-VEGF therapy saw a 22% higher ORR and lived 2.6 months longer without disease progression, though overall survival data is still being collected.The company said the new data supports plans to move sirexatamab into a phase 3 trial, focusing on colorectal cancer patients with elevated DKK1 protein levels or no prior anti-VEGF therapy.The company's shares were up more ","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["LENZ","BK4139","LPTX","BK4505","BK4563"],"gpt_icon":1},{"id":"2522787346","title":"BRIEF-Leap Therapeutics Reports Fourth Quarter And FY 2024 Results","url":"https://stock-news.laohu8.com/highlight/detail?id=2522787346","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2522787346?lang=en_us&edition=fundamental","pubTime":"2025-03-26 19:18","pubTimestamp":1742987911,"startTime":"0","endTime":"0","summary":"BRIEF-Leap Therapeutics Reports Fourth Quarter And FY 2024 ResultsMarch 26 (Reuters) - Leap Therapeutics Inc LPTX.O:LEAP THERAPEUTICS REPORTS FOURTH QUARTER AND FULL YEAR 2024 FINANCIAL RESULTSSource text: ID:nPnbxNkGMaFurther company coverage: LPTX.O ((Reuters.Briefs@thomsonreuters.com;))","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250326:nTUA9KNBQL:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4505","LPTX","BK4139","BK4563"],"gpt_icon":0},{"id":"2522000820","title":"Leap Therapeutics Q4 Operating Expenses USD 16.125 Million","url":"https://stock-news.laohu8.com/highlight/detail?id=2522000820","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2522000820?lang=en_us&edition=fundamental","pubTime":"2025-03-26 19:05","pubTimestamp":1742987103,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250326:nPLX428874:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["LPTX","BK4505","BK4563","BK4139"],"gpt_icon":0},{"id":"2522187556","title":"Leap Therapeutics Reports Fourth Quarter and Full Year 2024 Financial Results","url":"https://stock-news.laohu8.com/highlight/detail?id=2522187556","media":"PR Newswire","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2522187556?lang=en_us&edition=fundamental","pubTime":"2025-03-26 19:05","pubTimestamp":1742987100,"startTime":"0","endTime":"0","summary":"Leap to host a conference call to present updated CRC clinical data today, March 26, 2025, at 8:00 a.m. ET. CAMBRIDGE, Mass., March 26, 2025 /PRNewswire/ -- Leap Therapeutics, Inc. , a biotechnology company focused on developing targeted and immuno-oncology therapeutics, today reported financial results for the fourth quarter and year ended December 31, 2024.Reported positive updated data from Part B of the Phase 2 DeFianCe study of sirexatamab  in second-line patients with advanced microsatellite stable  colorectal cancer  confirming:. Statistically significant 22% higherORR and 2.6 month longer PFS in patients who had not had prior anti-VEGF therapy. FL-501 abstract accepted for poster presentation at the 2025 American Association for Cancer Research  Annual Meeting.Across the intent-to-treat population, thesirexatamab Experimental Arm had improved ORR compared to the Control Arm, with PFS and OS maturing with a higher number of patients continuing to","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"yahoofinance","url":"https://finance.yahoo.com/news/leap-therapeutics-reports-fourth-quarter-110500189.html","rn_cache_url":null,"customStyle":"img, svg { display: none !important; }","selectors":"article","filters":"","directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/leap-therapeutics-reports-fourth-quarter-110500189.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["LPTX","LU0348723411.USD","BK4097","BK4139","BK4195","IE00BMPRXR70.SGD","BK4543","BK4609","BK4211","BK4141","PFS","ORR","LU0456854461.SGD","CRC","BK4588","BK4585","IE00BMPRXN33.USD","LU0266512127.USD","OS","IE00BMPRXQ63.HKD","LENZ","BK4563","BK4113","BK4213","BK4505","MSS"],"gpt_icon":1},{"id":"2522472820","title":"Leap Therapeutics Reports Positive Updated Data From Sirexatamab Colorectal Cancer Study","url":"https://stock-news.laohu8.com/highlight/detail?id=2522472820","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2522472820?lang=en_us&edition=fundamental","pubTime":"2025-03-26 19:00","pubTimestamp":1742986807,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250326:nTUA852XK6:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4139","LPTX","BK4563","BK4505"],"gpt_icon":0},{"id":"2522596875","title":"Leap Therapeutics Reports Positive Updated Data from Sirexatamab Colorectal Cancer Study","url":"https://stock-news.laohu8.com/highlight/detail?id=2522596875","media":"PR Newswire","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2522596875?lang=en_us&edition=fundamental","pubTime":"2025-03-26 19:00","pubTimestamp":1742986800,"startTime":"0","endTime":"0","summary":"Updated data confirms statistically significant 32% higher ORR and 3.5 month longer PFSin second-line CRC patients with high DKK1 levels treated with sirexatamab plus bevacizumab and chemotherapy. Statistically significant 22% higher ORR and 2.6 month longer PFSin patients who had not had prioranti-VEGF therapy. Leap to host a conference call to present clinical data today, March 26, 2025, at 8:00 a.m. ET. \"The updated data from Part B of the DeFianCe study presented today confirms that sirexatamab can generate significantly higher ORR and longer PFS in CRC patients who have high levels of DKK1 or who have not had prior anti-VEGF therapy, two exploratory populations with strong scientific rationale. In the full intent-to-treat population, sirexatamab demonstrated a higher ORR and a tail population with longer PFS that continues to mature. 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