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While broader equity markets have surged to new highs during the first half of 2025 (although hardly in a straight line!), during the first half of 2025, biotechnology experienced one if its worst periods of relative performance.We are reminded that biotech is a sector that, historically, has delivered compelling risk adjusted returns over the long term, with a low correlation to overall equity markets:. Figure 1: S&P Biotechnology Index Since Inception  returns in AUD vs ASX200 to 30 Jun 2025. However, biotech has more recently experienced some of its largest relative underperformance compared to overall markets in the index's history, in this case compared to the ASX200 . The first occurrence being during the first half of 2022 and again more recently in the first half of 2025:. 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