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The company has had a difficult Q1 as charitable foundation funding gaps and weaker-than-expected Syfovre sales weigh on the outlook, BofA Securities said in a report. BofA downgraded the stock to neutral from buy.Iovance Biotherapeutics  shares tumbled 46% after it lowered its 2025 product revenue guidance. Its Q1 results also missed estimates.MeiraGTx  shares added 1.0% after its investigational gene therapy, AAV-GAD, received regenerative medicine advanced therapy designation from the US Food and Drug Administration for the treatment of Parkinson's disease.","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["BK4139","IOVA","BK4588","BK4585","BK4505","BK4581","LU1093756325.SGD","IBB","LU1093756168.USD","XLV","APLS","MGTX"],"gpt_icon":0},{"id":"2534344554","title":"Iovance Biotherapeutics Stock Sinks 46%. Here's Why the Biotech Is Tumbling. -- Barrons.com","url":"https://stock-news.laohu8.com/highlight/detail?id=2534344554","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2534344554?lang=en_us&edition=fundamental","pubTime":"2025-05-09 23:33","pubTimestamp":1746804780,"startTime":"0","endTime":"0","summary":"Iovance Biotherapeutics stock was tumbling Friday after the oncology drug maker posted a wider-than-expected first-quarter loss.The company reported a loss of 36 cents a share on revenue of $49 million, well short of Wall Street's calls for a loss of 24 cents on revenue of $82 million.Iovance shares were down 46% to $1.72 on Friday.Management pinned the disappointing first-quarter results on reduced production capacity due to annual maintenance at its Iovance Cell Therapy Center.\"Since full production has now resumed at the [Cell Therapy Center], we now expect infusions to grow in the second quarter as compared to the first quarter,\" said interim CEO Frederick Vogt.Analysts at H.C. Wainwright reduced their price target on the stock to $20 from $32 in a research note Friday, but they reiterated a Buy rating due in part to the potential of Iovance's melanoma drug Amtagvi.Iovance expects regulatory approval for Amtagvi in the European Union, United Kingdom, and Canada this year. 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Analysts polled by FactSet were looking for a loss of $77.8 million, or 24 cents a share.Revenue for the quarter was $49.3 million, compared with last year's $715,000 and the $82.4 million analysts expected.Iovance said its first-quarter revenue was affected by a significant reduction in capacity during an annual scheduled maintenance at its Iovance Cell Therapy Center. Full production has now resumed at the center, so the company now expects infusions to grow in the second quarter as compared with the first quarter.As of March 31, Iovance had cash, cash equivalents, investments and restricted cash of $366 million. The current cash position and anticipated product r","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IOVA","BK4139"],"gpt_icon":0},{"id":"1182969175","title":"Stock Track | Iovance Biotherapeutics Plummets 39.43% After Q1 Earnings Miss and Slashed Revenue Guidance","url":"https://stock-news.laohu8.com/highlight/detail?id=1182969175","media":"Stock Track","labels":["movement"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/1182969175?lang=en_us&edition=fundamental","pubTime":"2025-05-09 21:42","pubTimestamp":1746798135,"startTime":"0","endTime":"0","summary":"Shares of Iovance Biotherapeutics, Inc.  experienced a dramatic plunge of 39.43% in Friday's pre-market trading session, following the release of disappointing first-quarter 2025 financial results and a significant downward revision of its full-year guidance.Adding to investor concerns, Iovance Biotherapeutics slashed its fiscal year 2025 total product revenue guidance to a range of $250 million to $300 million, down from previous projections. 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