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Addex’s lead drug candidate, dipraglurant , is under evaluation for future development in brain injury recovery, including post-stroke and traumatic brain injury recovery. Addex’s partner, Indivior, has selected a GABAB PAM drug candidate for development in substance use disorders and has successfully completed IND enabling studies. Addex is advancing an independent GABAB PAM program for chronic cough. 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The agreement also includes a research collaboration under which the Sinntaxis team will complete evaluation of Addex’s dipraglurant, an orally active mGlu5 negative allosteric modulator , for the treatment of brain injury recovery.About mGluR5 NAMs and Brain InjuryFunctional recovery following stroke relies on the formation of new or reactivation of existing neural connections. Accumulating evidence suggests that the mGlu5 receptor modulates brain plasticity and function. A paper published in BRAIN*, titled “Inhibiti","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/addex-enters-option-agreement-sinntaxis-050000079.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"corporation","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["ADXN","BK4139","BK4007"],"gpt_icon":0},{"id":"2530925629","title":"Addex Reports Full Year 2024 Financial Results and Provides Corporate Update","url":"https://stock-news.laohu8.com/highlight/detail?id=2530925629","media":"GlobeNewswire","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2530925629?lang=en_us&edition=fundamental","pubTime":"2025-04-25 13:00","pubTimestamp":1745557200,"startTime":"0","endTime":"0","summary":"Launched Neurosterix with Perceptive Advisors, raising USD 65 million in Series A to advance preclinical portfolio. Indivior selected GABAB PAM drug candidate and started IND enabling studies for development in substance use disorders. Addex selected independent GABAB PAM drug candidate for development in chronic cough. Repositioned our phase 2 mGlu5 NAM asset, dipraglurant in brain injury recovery. Regained rights to our phase 2 mGlu2 PAM asset, ADX71149. Geneva, Switzerland, April 25, 2025 - Addex Therapeutics , a clinical-stage biopharmaceutical company focused on developing a portfolio of novel small molecule allosteric modulators for neurological disorders, today reported its full-year 2024 financial results for the period ended December 31, 2024 and provided a corporate 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