March 27 (Reuters) - Wall Street's main indexes fell on Friday as the month-long war in the Middle East dragged on, weighing on sentiment, while investors watched for any signs of de-escalation. .N

At 11:30 EDT, the Dow Jones Industrial Average .DJI was down 0.71% at 45,632.17. The S&P 500 .SPX was down 0.67% at 6,433.77, and the Nasdaq Composite .IXIC was down 1.07% at 21,179.27.

The top three S&P 500 .PG.INX percentage gainers:

** Entergy Corp ETR.N, up 7.3%

** Brown-Forman Corp BFb.N, up 5.7%

** Campbell's Co CPB.OQ, up 5.3%

The top three S&P 500 .PL.INX percentage losers:

** Coinbase Global Inc COIN.OQ, down 6.9%

** Datadog Inc DDOG.OQ, down 6.7%

** CrowdStrike Holdings Inc CRWD.OQ, down 5.5%

The top three NYSE .PG.N percentage gainers:

** System1 Inc SST.N, up 73.7%

** Argan Inc AGX.N, up 33.9%

** Innovate Corp VATE.N, up 16.6%

The top three NYSE .PL.N percentage losers:

** Burford Capital Ltd BUR.N, down 36.8%

** Blacksky Technology Inc BKSY.N, down 15.3%

** BitGo Holdings Inc BTGO.N, down 12.2%

The top three Nasdaq .PG.O percentage gainers:

** Artelo Biosciences Inc ARTL.OQ, up 250.8%

** Hitek Global Inc HKIT.OQ, up 114.7%

** VisionSys AI Inc VSA.OQ, up 64.2%

The top three Nasdaq .PL.O percentage losers:

** Iterum Therapeutics PLC ITRM.OQ, down 75.2%

** Fitness Champs Holdings Ltd FCHL.OQ, down 46.3%

** Shuttle Pharmaceuticals Holdings Inc SHPH.OQ, down 37.9%

** Pony AI Inc PONY.O:BUZZ - HK shares hit record low on quarterly profit margin miss nL1N40F035

** Wix.com Ltd WIX.O:BUZZ - Falls after JP Morgan cuts to 'underweight' rating nL4N40F0K4

** SailPoint Inc SAIL.O:

** CrowdStrike Holdings Inc CRWD.O:

** Fortinet Inc FTNT.O:

** Palo Alto Networks Inc PANW.O:

BUZZ - Cybersecurity outlook 'cautiously optimistic' as AI drives spending, Scotiabank says nL4N40F0MP

BUZZ - Cybersecurity stocks slide after report on Anthropic's new advanced AI model nL4N40F16M

** Datacentrex Inc DTCX.O:BUZZ - Plummets on deep-discounted equity raise nL6N40F0NW

** Phathom Pharmaceuticals Inc PHAT.O:BUZZ - Barclays raises Phathom Pharmaceuticals to 'overweight'; shares rise nL4N40F0RA

** Argan Inc AGX.N:BUZZ - Shares climb after strong Q4 revenue growth nL6N40F0NQ

** Honeywell International Inc HON.O:BUZZ - Gets 'outperform' rating as BMO starts coverage nL4N40F0TR

** Eaton Corporation PLC ETN.N:

** Emerson Electric Co EMR.N:

** Ametek Inc AME.N:

BUZZ - BMO initiates coverage on US industrial manufacturers, lifts long-term outlook nL4N40F0TV

** Rocket Pharmaceuticals Inc RCKT.O:BUZZ - Rises after FDA approves gene therapy for fatal childhood disorder nL4N40F0TQ

** Dover Corp DOV.N:BUZZ - BMO starts Dover coverage with 'market perform' nL4N40F0V5

** Quanta Services Inc PWR.N:BUZZ - Rises after BMO lifts to 'outperform' nL4N40F0W5

** Parker-Hannifin Corp PH.N:BUZZ - Gets 'outperform' rating as BMO starts coverage nL4N40F0W2

** IDEX Corp IEX.N:BUZZ - Gets 'marketperform' rating as BMO starts coverage nL4N40F0WJ

** Lantern Pharma Inc LTRN.O:BUZZ - Up after FDA allows trial of pediatric brain cancer drug nL4N40F0W1

** Alphabet Inc GOOGL.O:BUZZ - Down; Needham suggests addiction ruling impact overblown nL4N40F0RT

** Two Harbors Investment Corp TWO.N:BUZZ - Dips after announcing acquisition by CrossCountry Mortgage, ending UWM deal nL6N40F0R7

** Vor Biopharma Inc VOR.O:BUZZ - Climbs after announcing $75 mln private placement nL6N40F0RO

** ADMA Biologics Inc ADMA.O:BUZZ - Rises after rejecting short-seller's claims nL4N40F0YP

** Zenas BioPharma Inc ZBIO.O:BUZZ - Slides on $300 mln convertible bond, stock sales nL6N40F0S8

** Walt Disney Co DIS.N:BUZZ - Biggest challenge includes improving IP output, Wells Fargo says nL4N40F0W0

** Iterum Therapeutics PLC ITRM.O:BUZZ - Plummets after filing wind up petition nL4N40F17W

** Bitgo Holdings Inc BTGO.N:BUZZ - Slides after posting Q4 loss nL4N40F16I

** Carnival Corp CCL.N:BUZZ - Falls as annual profit forecast cut nL6N40F0VH

** Entergy Corp ETR.N:BUZZ - Gains on revised Meta data-center deal nL4N40F179

** AnaptysBio Inc ANAB.O:BUZZ - Falls after board approves First Tracks Biotherapeutics spinoff nL4N40F12W

** Forgent Power Solutions Inc FPS.N:BUZZ - Slips as PE backer cuts stake in $885 mln secondary offering nL6N40F0VG

(Compiled by Rajarshi Roy and Pragyan Kalita)

((Pragyan.Kalita@thomsonreuters.com))