Bicycle Therapeutics announced that results from a Phase 1/2 study of its EphA2-targeting Bicycle Drug Conjugate BT5528 in combination with nivolumab in patients with advanced solid tumors will be presented in a poster session at the AACR Annual Meeting 2026 on April 20. The company also said it will present future preclinical assessments of BT5528 anti-tumor activity in xenograft models of head and neck squamous cell carcinoma on April 19 and pancreatic ductal adenocarcinoma on April 21. In addition, a poster on EphA2 expression in muscle-invasive bladder cancer and its association with Nectin-4 and HER2 is scheduled for presentation on April 19. A separate poster describing development and first clinical experiences of an EphA2-specific PET imaging bicyclic peptide is slated for April 21.
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