Wall Street's main indexes were mixed on Wednesday, with the S&P 500 and the Dow coming off their intraday record highs after rallying in the previous two sessions, while investors assessed numerous economic datasets. .N

At 10:30 EST, the Dow Jones Industrial Average .DJI was down 0.46% at 49,231.71. The S&P 500 .SPX was down 0.02% at 6,943.15, and the Nasdaq Composite .IXIC was up 0.28% at 23,614.16.

The top three S&P 500 .PG.INX percentage gainers:

** Intel Corp INTC.OQ, up 11.0%

** Valero Energy Corp VLO.N, up 4.6%

** Healthpeak Properties Inc DOC.N, up 4.1%

The top three S&P 500 .PL.INX percentage losers:

** Skyworks Solutions Inc SWKS.OQ, down 10.7%

** First Solar Inc FSLR.OQ, down 9.2%

** Western Digital Corp WDC.OQ, down 8.1%

The top three NYSE .PG.N percentage gainers:

** Anywhere Real Estate Inc HOUS.N, up 13.8%

** Biohaven Ltd BHVN.N, up 12.3%

** PSQ Holdings Inc PSQH.N, up 11.6%

The top three NYSE .PL.N percentage losers:

** North European Oil Royalty Trust NRT.N, down 10.3%

** Endeavour Silver Corp EXK.N, down 10.2%

** Wolverine World Wide Inc <WWW.N>, down 9.7%

The top three Nasdaq .PG.O percentage gainers:

** Nuvve Holding Corp NVVE.OQ, up 65.0%

** Monte Rosa Therapeutics Inc GLUE.OQ, up 54.8%

** SMX (Security Matters) PLC SMX.OQ, up 44.3%

The top three Nasdaq .PL.O percentage losers:

** Ascent Solar Technologies Inc ASTI.OQ, down 24.4%

** Curis Inc CRIS.OQ, down 16.9%

** TryHard Holdings Ltd THH.OQ, down 16.5%

** Lockheed Martin Corp LMT.N:

** RTX Corp RTX.N:BUZZ - Jefferies starts Italy's Avio at 'buy' on expansion to US market nL6N3Y80ET

** Hecla Mining Co HL.N:

** Coeur Mining Inc CDE.N:

** Endeavour Silver Corp EXK.N:

** Silvercorp Metals Inc SVM.N:

BUZZ - Silver miners plunge as metal prices drop due to dollar strength nL6N3Y80UJ

** Newmont Corp NEM.N:

** Gold Fields Ltd GFI.N:

** Harmony Gold Mining Co Ltd HMY.N:

** Sibanye Stillwater Ltd SBSW.N:

BUZZ - Gold miners fall as investors book profit nL6N3Y80UQ

** Colgate-Palmolive Co CL.N:BUZZ - Shares climb on Piper Sandler upgrade to 'overweight' nL6N3Y80HF

** Ventyx Biosciences Inc VTYX.O:BUZZ - Soars as report says Eli Lilly eyes $1 billion acquisition nL6N3Y80JJ

** Strategy Inc MSTR.O:BUZZ - Gains as MSCI keeps crypto treasury firms in indexes nL6N3Y80KV

** Deckers Outdoor Corp DECK.N:BUZZ - Falls after Piper Sandler downgrades to 'underweight' rating nL6N3Y80L5

** Penguin Solutions Inc PENG.O:BUZZ - Gains after Q1 results beat estimates nL6N3Y80LC

** AST SpaceMobile Inc ASTS.O:BUZZ - Drops as Scotiabank downgrades rating nL6N3Y80K2

** Arthur J. Gallagher & Co AJG.N:BUZZ - Piper Sandler downgrades Arthur J. Gallagher to 'neutral' nL4N3Y80NV

** GameStop Corp GME.N:BUZZ - Climbs as CEO's pay tied to $100 billion valuation target nL6N3Y80UO

** Crinetics Pharmaceuticals Inc CRNX.O:BUZZ - Climbs after $350 mln stock sale nL6N3Y80N2

** First Solar Inc FSLR.O:BUZZ - Dips as Jefferies downgrades rating to 'hold' nL6N3Y80M1

** AAR Corp AIR.N:BUZZ - Rises after Q2 profit beat nL6N3Y80NI

** Hershey Co HSY.N:BUZZ - Rises after Piper Sandler upgrades to 'overweight' nL6N3Y80G5

** Monte Rosa Therapeutics Inc GLUE.O:BUZZ - Rises as heart drug shows promise in early-stage trial nL4N3Y80RV

** Arrowhead Pharmaceuticals Inc ARWR.O:BUZZ - Slips after unveiling convertible, stock deals nL6N3Y80NZ

** Rezolute Inc RZLT.O:BUZZ - Rises as drug shows promise for rare low blood sugar disorders nL4N3Y80SR

** Apogee Enterprises Inc APOG.O:BUZZ - Forecasts weak 2026 profit; shares slide nL4N3Y80QN

** M&T Bank Corp MTB.N:BUZZ - BofA Global Research downgrades M&T Bank to 'neutral' nL4N3Y80T8

** Vera Therapeutics Inc VERA.O:BUZZ - Soars as FDA accepts priority review for kidney disease drug nL4N3Y80UK

** Compass Inc COMP.N:BUZZ - Jumps after announcing convertible for Anywhere Real Estate merger, encouraging Q4 guidance nL6N3Y80VD

** Union Pacific Corp UNP.N:BUZZ - BMO cuts Union Pacific to 'market perform' on weak freight demand nL4N3Y80TC

** Critical Metals Corp CRML.O:BUZZ - Rises as Trump weighs Greenland acquisition, rare earths stake nL6N3Y80P9

** Sandisk Corp SNDK.O:BUZZ - BofA Global Research raises PT on Sandisk to $390 nL4N3Y80WW

** Humana Inc HUM.N:BUZZ - Dips as Wells Fargo downgrades to "equal weight" nL6N3Y80S0

** Praxis Precision Medicines Inc PRAX.O:BUZZ - Edges down after $575 mln stock sale nL6N3Y80SF

** Cal-Maine Foods Inc CALM.O:BUZZ - Up after second-quarter profit beats estimates nL6N3Y80O6

** Oklo Inc OKLO.N:BUZZ - Signs deal with DOE to build radioisotope pilot plant; shares fall nL4N3Y80X2

** Halliburton Co HAL.N:

** SLB NV SLB.N:

** Baker Hughes Co BKR.O:

** Liberty Energy Inc LBRT.NBUZZ - US oilfield services companies gain as Wright announces Washington's intention to resume Venezuelan oil flows nL4N3Y80ZG

BUZZ - TD Cowen changes PT on US oilfield services companies nL4N3Y80VB

** Netflix Inc NFLX.O:BUZZ - Gains as Warner Bros Discovery rejects Paramount's revised bid nL6N3Y80LM

** Albertsons Companies Inc ACI.N:BUZZ - Falls after co forecasts tepid annual sales, profit nL6N3Y80QH

** Alumis Inc ALMS.O:BUZZ - Extends gains after commencing $175 mln stock offering nL6N3Y80UC

** UniFirst Corp UNF.N:BUZZ - Falls after Q1 profit miss nL6N3Y80RK

** Micron Technology Inc MU.O:

BUZZ - UBS raises Micron Technology PT on memory upcycle nL6N3Y80W8

(Compiled by Rajarshi Roy and Varun Sahay)

((Varun.sahay@thomsonreuters.com))