Merck Unveils Promising Early Data for MK-1045 and Bomedemstat in Hematologic Cancers at ASH 2025

Reuters

Nov 24

Merck Unveils Promising Early Data for MK-1045 and Bomedemstat in Hematologic Cancers at ASH 2025

Merck & Co. Inc. announced that new data from its hematology pipeline will be presented at the American Society of Hematology $(ASH)$ Annual Meeting and Exposition in December 2025. The company will share results from multiple investigational therapies, including the first clinical presentation of MK-1045, a novel CD19xCD3 T-cell engager, in adults with relapsed or refractory B-cell acute lymphoblastic leukemia. Additionally, Merck will present initial results from the Phase 2 Shorespan-004 study of bomedemstat (MK-3543), an LSD1 inhibitor, in patients with polycythemia vera who are resistant or intolerant to cytoreductive therapy. Updated data on nemtabrutinib (MK-1026), a non-covalent BTK inhibitor, and zilovertamab vedotin (MK-2140), an antibody-drug conjugate targeting ROR1, are also scheduled for presentation. The results have not yet been presented and will be disclosed at the ASH 2025 meeting.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Merck & Co. Inc. published the original content used to generate this news brief via Business Wire (Ref. ID: 20251124225525) on November 24, 2025, and is solely responsible for the information contained therein.

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Inc. announced that new data from its hematology pipeline will be presented at the American Society of Hematology <a href=\"https://laohu8.com/S/ASH\">$(ASH)$</a> Annual Meeting and Exposition in December 2025. The company will share results from multiple investigational therapies, including the first clinical presentation of MK-1045, a novel CD19xCD3 T-cell engager, in adults with relapsed or refractory B-cell acute lymphoblastic leukemia. Additionally, Merck will present initial results from the Phase 2 Shorespan-004 study of bomedemstat (MK-3543), an LSD1 inhibitor, in patients with polycythemia vera who are resistant or intolerant to cytoreductive therapy. Updated data on nemtabrutinib (MK-1026), a non-covalent BTK inhibitor, and zilovertamab vedotin (MK-2140), an antibody-drug conjugate targeting ROR1, are also scheduled for presentation. 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Inc. announced that new data from its hematology pipeline will be presented at the American Society of Hematology <a href=\"https://laohu8.com/S/ASH\">$(ASH)$</a> Annual Meeting and Exposition in December 2025. The company will share results from multiple investigational therapies, including the first clinical presentation of MK-1045, a novel CD19xCD3 T-cell engager, in adults with relapsed or refractory B-cell acute lymphoblastic leukemia. Additionally, Merck will present initial results from the Phase 2 Shorespan-004 study of bomedemstat (MK-3543), an LSD1 inhibitor, in patients with polycythemia vera who are resistant or intolerant to cytoreductive therapy. Updated data on nemtabrutinib (MK-1026), a non-covalent BTK inhibitor, and zilovertamab vedotin (MK-2140), an antibody-drug conjugate targeting ROR1, are also scheduled for presentation. The results have not yet been presented and will be disclosed at the ASH 2025 meeting.\n      </p>\n</div><div xmlns:xsd=\"http://www.w3.org/2001/XMLSchema\" xmlns:xsi=\"http://www.w3.org/2001/XMLSchema-instance\">\n<em>Disclaimer: <span>This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Merck &amp; Co. Inc. published the original content used to generate this news brief via Business Wire (Ref. ID: 20251124225525) on November 24, 2025, and is solely responsible for the information contained therein.</span></em>\n</div></body></html>\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"LU1941712348.USD","symbol_name":"ALLIANZ PET AND ANIMAL WELLBEING \"AT\" (USD) ACC","start_time":0,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251124:nNDL3C1CQr:1","article_id":"2585469125","we_media_id":"1032215980","thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2585469125","pubTimestamp":1763984722,"columns":[],"sourceInfo":null,"weMediaInfo":{"media_name":"Reuters","introduction":"Reuters.com brings you the latest news from around the world, covering breaking news in markets, business, politics, entertainment and technology","home_visible":1,"id":"1032215980","head_image":"https://community-static.tradeup.com/news/4567337cbdf294b657b1fa87c5488b48"},"summary":"Merck & Co. Inc. announced that new data from its hematology pipeline will be presented at the American Society of Hematology  Annual Meeting and Exposition in December 2025. The company will share results from multiple investigational therapies, including the first clinical presentation of MK-1045, a novel CD19xCD3 T-cell engager, in adults with relapsed or refractory B-cell acute lymphoblastic leukemia. Additionally, Merck will present initial results from the Phase 2 Shorespan-004 study of bomedemstat , an LSD1 inhibitor, in patients with polycythemia vera who are resistant or intolerant to cytoreductive therapy. Updated data on nemtabrutinib , a non-covalent BTK inhibitor, and zilovertamab vedotin , an antibody-drug conjugate targeting ROR1, are also scheduled for presentation. The results have not yet been presented and will be disclosed at the ASH 2025 meeting.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. 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VL \"A\" (USD) ACC","LU1989772923.USD":"CPR Invest - Climate Action A2 Acc USD-H"},"translate_title":"默克在ASH 2025上公布了MK-1045和Bomedemstat治疗血液癌症的有希望的早期数据","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"MRK":0.9},"content_text":"Merck Unveils Promising Early Data for MK-1045 and Bomedemstat in Hematologic Cancers at ASH 2025\n    \n\n        Merck & Co. Inc. announced that new data from its hematology pipeline will be presented at the American Society of Hematology $(ASH)$ Annual Meeting and Exposition in December 2025. The company will share results from multiple investigational therapies, including the first clinical presentation of MK-1045, a novel CD19xCD3 T-cell engager, in adults with relapsed or refractory B-cell acute lymphoblastic leukemia. Additionally, Merck will present initial results from the Phase 2 Shorespan-004 study of bomedemstat (MK-3543), an LSD1 inhibitor, in patients with polycythemia vera who are resistant or intolerant to cytoreductive therapy. Updated data on nemtabrutinib (MK-1026), a non-covalent BTK inhibitor, and zilovertamab vedotin (MK-2140), an antibody-drug conjugate targeting ROR1, are also scheduled for presentation. The results have not yet been presented and will be disclosed at the ASH 2025 meeting.\n      \n\nDisclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Merck & Co. Inc. published the original content used to generate this news brief via Business Wire (Ref. 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