Oric Pharmaceuticals Reports Promising Phase 1b Results for ORIC-944 in Prostate Cancer Trial

Reuters

Nov 14, 2025

Oric Pharmaceuticals Reports Promising Phase 1b Results for ORIC-944 in Prostate Cancer Trial

Oric Pharmaceuticals Inc. announced additional efficacy and safety data from the Phase 1b clinical trial evaluating ORIC-944 in combination with androgen receptor inhibitors for patients with metastatic castration-resistant prostate cancer (mCRPC). The trial demonstrated a 55% PSA50 response rate and a 20% PSA90 response rate, with rapid and deep ctDNA reductions observed in 76% of patients and ctDNA clearance in 59%. Safety and tolerability profiles were reported as compatible with long-term dosing, with most adverse events being Grade 1 or 2. The company plans to present dose optimization data in the first quarter of 2026, ahead of initiating a global Phase 3 registrational trial in mCRPC in the first half of next year.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Oric Pharmaceuticals Inc published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9575459-en) on November 13, 2025, and is solely responsible for the information contained therein.

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ID: GNW9575459-en) on November 13, 2025, and is solely responsible for the information contained therein.</span></em>\n</div></body></html>\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"BK4112","symbol_name":"金融交易所和数据","start_time":0,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251113:nNDLbg5d1p:1","article_id":"2583751100","we_media_id":"1032215980","thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2583751100","pubTimestamp":1763067933,"columns":[],"sourceInfo":null,"weMediaInfo":{"media_name":"Reuters","introduction":"Reuters.com brings you the latest news from around the world, covering breaking news in markets, business, politics, entertainment and technology","home_visible":1,"id":"1032215980","head_image":"https://community-static.tradeup.com/news/4567337cbdf294b657b1fa87c5488b48"},"summary":"Oric Pharmaceuticals Inc. announced additional efficacy and safety data from the Phase 1b clinical trial evaluating ORIC-944 in combination with androgen receptor inhibitors for patients with metastatic castration-resistant prostate cancer . 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The trial demonstrated a 55% PSA50 response rate and a 20% PSA90 response rate, with rapid and deep ctDNA reductions observed in 76% of patients and ctDNA clearance in 59%. Safety and tolerability profiles were reported as compatible with long-term dosing, with most adverse events being Grade 1 or 2. The company plans to present dose optimization data in the first quarter of 2026, ahead of initiating a global Phase 3 registrational trial in mCRPC in the first half of next year.\n      \n\nDisclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Oric Pharmaceuticals Inc published the original content used to generate this news brief via GlobeNewswire (Ref. 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