Zai Lab Launches Global Phase 3 Trial of DLL3-Targeted ADC for Small Cell Lung Cancer
Reuters
Oct 24
Zai Lab Launches Global Phase 3 Trial of DLL3-Targeted ADC for Small Cell Lung Cancer
Zai Lab Ltd. has announced updated data from its global Phase 1 clinical trial of zocilurtatug pelitecan (zoci), formerly known as ZL-1310, a DLL3-targeted antibody-drug conjugate $(ADC)$ for patients with previously treated extensive-stage small cell lung cancer (ES-SCLC). The results demonstrated robust and durable responses in heavily pre-treated patients. These data were presented as an oral presentation during the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, held October 22-26, 2025, in Boston, Massachusetts. Zai Lab also announced the initiation of a global Phase 3 registrational study for zoci and plans to expand its clinical development into first-line small cell lung cancer and neuroendocrine carcinoma, with registrational studies expected to begin next year.
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