European equities traded in the US as American depositary receipts were sharply lower late Tuesday morning, falling 1.12% to 1,504.34 on the S&P Europe Select ADR Index.

From continental Europe, the gainers were led by medical device maker EDAP TMS (EDAP) and pharmaceutical company Ascendis Pharma (ASND), which climbed 22% and 3.9%, respectively. They were followed by consumer goods company Unilever (UL) and petroleum refiner Equinor (EQNR), which were up 0.6% each.

The decliners from continental Europe were led by biopharmaceutical companies Genfit (GNFT) and Grifols (GRFS), which fell 4.1% and 3.2%, respectively. They were followed by internet advertising firm Criteo (CRTO) and biopharmaceutical company DBV Technologies (DBVT), which dropped 2.2% each.

From the UK and Ireland, the gainers were led by biopharmaceutical companies Amarin (AMRN) and Mereo BioPharma Group (MREO), which rose 3.9% each. They were followed by pharmaceutical company Silence Therapeutics (SLN) and biopharmaceutical company Bicycle Therapeutics (BCYC), which were up 2.9% and 2.6%, respectively.

The decliners from the UK and Ireland were led by biopharmaceutical company Akari Therapeutics (AKTX) and tobacco company British American Tobacco (BTI), which dropped 21% and 3.9%, respectively. They were followed by cruise line operator Carnival (CUK) and utilities company National Grid (NGG), which were down 3.4% each.