Actinium Pharmaceuticals Unveils Promising Preclinical Data for ATNM-400, Showcasing Superior Efficacy in Overcoming Prostate Cancer Treatment Resistance

Reuters
23 Jun
Actinium Pharmaceuticals Unveils Promising Preclinical Data for ATNM-400, Showcasing Superior Efficacy in Overcoming Prostate Cancer Treatment Resistance

NEW YORK, June 23, 2025 -- Actinium Pharmaceuticals, Inc. (NYSE AMERICAN: ATNM) has announced new preclinical data for its prostate cancer candidate, ATNM-400, at the Society of Nuclear Medicine & Molecular Imaging (SNMMI) annual meeting in New Orleans, Louisiana. The data indicate that ATNM-400, which utilizes the alpha-particle emitter Actinium-225 (Ac-225), demonstrates superior efficacy compared to the androgen receptor inhibitor Xtandi® (enzalutamide) and is effective in Xtandi® resistant prostate models. Additionally, ATNM-400 outperformed the PSMA-617 radiotherapies labeled with Lutetium-177 and Ac-225, showing potential to overcome resistance to Pluvicto® therapy. The presentation of these findings highlights ATNM-400's potential as a transformative therapy in prostate cancer treatment. Further details are available in the SNMMI presentation accessible on Actinium's website.

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