PepGen Reports First Quarter 2025 Financial Results and Recent Corporate Highlights

-- Reported positive DM1 patient data with mean splicing correction of 29.1% following a single dose of PGN-EDODM1 at 10 mg/kg --

-- FREEDOM-DM1 data from 15 mg/kg cohort expected in the second half of 2025 --

-- CONNECT1-EDO51 data from 10 mg/kg cohort expected in the third quarter of 2025 --

BOSTON--(BUSINESS WIRE)--May 08, 2025-- 

PepGen Inc. (Nasdaq: PEPG), a clinical-stage biotechnology company advancing the next generation of oligonucleotide therapies with the goal of transforming the treatment of severe neuromuscular and neurological diseases, today reported financial results and recent corporate highlights for the quarter ended March 31, 2025.

"Our EDO platform's unique ability to efficiently deliver oligonucleotides into the nuclei of cells is the foundation of our differentiated pipeline, with promising clinical data from two programs underscoring what we believe to be the broad potential of our technology, " said James McArthur, PhD, President and CEO of PepGen. "This is a pivotal and catalyst-rich 12 months for PepGen and for our DM1 and DMD clinical programs. Following the highly encouraging initial results from our FREEDOM-DM1 study reported in February, demonstrating potentially best-in-class splicing correction after a single therapeutic dose, we look forward to sharing data from the 15 mg/kg cohort in the second half of the year. We also expect to report dystrophin production data from the 10 mg/kg cohort of our CONNECT1-EDO51 study in patients with DMD in the third quarter. Collectively, we believe these data will build on the body of evidence supporting our platform's promise. Additionally, during the first quarter, we have undertaken various measures to extend our cash runway while prioritizing delivering on our key clinical milestones."

Recent Program Updates

PGN-EDODM1: Myotonic Dystrophy Type 1 $(DM1.AU)$

   -- Phase 1 FREEDOM-DM1 Single Ascending Dose (SAD) Randomized, 
      Placebo-Controlled Clinical Trial of PGN-EDODM1: 
 
          -- In February, the Company reported positive initial clinical data 
             from the 5 mg/kg and 10 mg/kg dose cohorts from the ongoing 
             FREEDOM trial. At day 28 following a single dose, PGN-EDODM1 was 
             observed to have a favorable emerging safety profile and robust, 
             dose-dependent splicing correction in the 5 and 10 mg/kg dose 
             cohorts. 
 
          -- PepGen expects to report safety, 28-day splicing and functional 
             benefit data from the 15 mg/kg cohort during the second half of 
             2025. 
   -- Phase 2 FREEDOM2-DM1 Multiple Ascending Dose $(MAD.AU)$ Randomized, 
      Placebo-Controlled Clinical Trial of PGN-EDODM1: 
 
          -- The Company expects to report results from the 5 mg/kg cohort of 
             the FREEDOM2 trial in the first quarter of 2026. 

PGN-EDO51: Duchenne Muscular Dystrophy (DMD)

   -- Phase 2 CONNECT1-EDO51 Open-Label MAD Clinical Trial of PGN-EDO51: 
 
          -- PepGen expects to report additional safety as well as dystrophin 
             production data from the 10 mg/kg cohort of the CONNECT1 trial in 
             DMD patients in the third quarter of 2025. 
   -- Phase 2 CONNECT2-EDO51 MAD Clinical Trial of PGN-EDO51: 
 
          -- In March 2025, the Company announced its voluntary decision to 
             pause the Phase 2 CONNECT2 trial in DMD patients until it can 
             review results from the 10 mg/kg cohort in the ongoing Phase 2 
             CONNECT1 trial. 

Corporate Updates

   -- In March 2025, PepGen announced that Lisa Wyman and Mitchell H. Finer, 
      PhD, joined the Company's Board of Directors. Each are industry veterans 
      bringing decades of executive and operational experience in life sciences 
      to the Company. 
 
   -- In March 2025, the Company gave two oral presentations and presented five 
      posters at the 2025 Muscular Dystrophy Association $(MDA)$ Clinical & 
      Scientific Conference. The oral presentations featured data from the 
      ongoing CONNECT1 clinical trial in DMD and the FREEDOM clinical trial in 
      DM1. 
 
   -- In May 2025, the Company made an oral presentation and presented two 
      posters at the 2025 Myotonic Dystrophy Foundation (MDF) Conference. 
      PepGen also presented at the 5th Edition of Euro-DyMA's Pharma Day, held 
      in conjunction with the MDF Conference. These presentations highlighted 
      the recently announced FREEDOM clinical data in DM1, as well as 
      proof-of-mechanism preclinical results for PGN-EDODM1. 

Financial Results for the Three Months Ended March 31, 2025

   -- Cash, Cash Equivalents and Marketable Securities were $97.8 million as of 
      March 31, 2025. Based on currently planned operations, the Company 
      believes that its existing cash, cash, equivalents, and marketable 
      securities will be sufficient to fund its operations for at least 12 
      months from the date of this release. 
 
   -- Research and Development Expenses were $25.4 million for the three months 
      ended March 31, 2025, compared to $14.7 million for the same period in 
      2024. 
 
   -- General and Administrative Expenses were $5.9 million for the three 
      months ended March 31, 2025, compared to $5.1 million for the same period 
      in 2024. 
 
   -- Net Loss was $30.2 million, or $(0.92) basic and diluted net loss per 
      share, for the three months ended March 31, 2025, compared to $18.0 
      million, or $(0.63) basic and diluted net loss per share, for the same 
      period in 2024. PepGen had approximately 32.7 million shares outstanding 
      on March 31, 2025. 

Upcoming Potential Milestones

3Q 2025: CONNECT1-EDO51 data from 10 mg/kg cohort expected

2H 2025: FREEDOM-DM1 data from 15 mg/kg cohort expected

1Q 2026: FREEDOM2-DM1 data from the 5 mg/kg cohort expected

About PGN-EDODM1

PGN-EDODM1, PepGen's investigational candidate in development for the treatment of DM1, utilizes the Company's proprietary Enhanced Delivery Oligonucleotide (EDO) technology to deliver a therapeutic oligonucleotide that is designed to restore the normal splicing function of MBNL1, a key RNA splicing protein. DM1 is a progressively disabling, life-shortening genetic disorder. DM1 is estimated to affect 40,000 people in the United States, and over 74,000 people in Europe. The U.S. Food and Drug Administration has granted PGN-EDODM1 both Orphan Drug and Fast Track Designations for the treatment of patients with DM1.

About PGN-EDO51

PGN-EDO51, PepGen's investigational candidate in development for the treatment of DMD, utilizes the Company's proprietary EDO technology to deliver a therapeutic oligonucleotide that is designed to target the root cause of this devastating disease. PGN-EDO51 is designed to skip exon 51 of the dystrophin transcript, an established therapeutic target for approximately 13% of DMD patients, thereby aiming to restore the open reading frame and enabling the production of a truncated, yet functional dystrophin protein. The U.S. Food and Drug Administration has granted PGN-EDO51 both Orphan Drug and Rare Pediatric Disease Designations for the treatment of patients with DMD amenable to an exon-51 skipping approach.

About PepGen

PepGen is a clinical-stage biotechnology company advancing the next generation of oligonucleotide therapies with the goal of transforming the treatment of severe neuromuscular and neurological diseases. PepGen's EDO platform is founded on over a decade of research and development and leverages cell-penetrating peptides to improve the uptake and activity of conjugated oligonucleotide therapeutics. Using these EDO peptides, we are generating a pipeline of oligonucleotide therapeutic candidates designed to target the root cause of serious diseases.

For more information, please visit PepGen.com. Follow PepGen on LinkedIn and X.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended. These statements may be identified by words such as "aims," "anticipates," "believes," "could," "estimates," "expects," "forecasts," "goal," "intends," "may," "plans," "possible," "potential," "seeks," "will," and variations of these words or similar expressions that are intended to identify forward-looking statements. Any such statements in this press release that are not statements of historical fact may be deemed to be forward-looking statements. These forward-looking statements include, without limitation, statements regarding the therapeutic potential and safety profile of our product candidates, including, based on early data, PGN-EDODM1 and PGN-EDO51, the expected timing for additional data reports from our FREEDOM Phase 1 trial and CONNECT1 Phase 2 trial and initial data from our FREEDOM2 Phase 2 trial, ongoing and planned regulatory interactions, and our financial resources and expected cash runway.

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