Release Date: November 12, 2024

For the complete transcript of the earnings call, please refer to the full earnings call transcript.

Positive Points

• Dyadic International Inc (NASDAQ:DYAI) reported a significant increase in revenue for Q3 2024, reaching approximately $1,958,000 compared to $397,000 for the same period a year ago.
• The company has successfully achieved multiple revenue streams through licensing agreements and milestone payments, including a $1 million license revenue from Proliant and a $425,000 success fee.
• Dyadic's proprietary C1 and DPAAS platforms are showing promising results in producing recombinant proteins and enzymes, which are crucial for various applications in health, nutrition, and wellness.
• The company is actively collaborating with top pharmaceutical companies and biotech firms, advancing projects in infectious disease vaccines and antibodies, which could lead to significant future growth.
• Dyadic is strategically positioned to capitalize on the growing demand for alternative proteins and biopharmaceuticals, with a focus on high-value markets such as cell culture media and animal-free dairy products.

Negative Points

• Despite the revenue growth, Dyadic International Inc (NASDAQ:DYAI) reported a net loss of $203,000 for Q3 2024, although this is an improvement from the $1,614,000 loss in the same period last year.
• Research and development expenses decreased, reflecting a winding down of activities related to the company's phase one clinical trial, which may indicate a slowdown in new internal research projects.
• The company faces high production costs for animal-free dairy products, which could impact profitability unless efficiencies are improved.
• There is a dependency on collaborations and partnerships for revenue generation, which may pose risks if any partnerships do not yield expected results.
• The market for recombinant proteins and enzymes is competitive, and Dyadic must continue to innovate and improve productivity to maintain its market position.

Q & A Highlights

• Warning! GuruFocus has detected 5 Warning Signs with DYAI.

Q: Could you explain the regulatory requirements for selling research-grade recombinant proteins? A: Joe Hazelton, COO: The main requirement is that manufacturing must be done at an ISO-certified facility. There is no regulatory review by an agency needed to launch these products, but product specifications for QA and QC must meet ISO standards.

Q: How many certificates of analysis do you currently have for your products? A: Joe Hazelton, COO: We have three certificates of analysis for DNAse One, Bovine Transferrin, and Bovine Alpha-Lactalbumin. These certificates confirm that our products perform comparably to existing commercial research-grade products.

Q: Can you elaborate on the production challenges and market dynamics for high-value research products? A: Joe Hazelton, COO: Production challenges vary by market. For example, serum albumin requires large quantities, while DNAse One is needed in smaller amounts due to its toxicity to most cell lines. Our advantage lies in producing at higher levels with lower costs, providing margin flexibility.

Q: How does the market view recombinant versus animal-derived products, particularly in terms of pricing and demand? A: Joe Hazelton, COO: Preferences depend on the market segment. Recombinant products are often preferred for their regulatory advantages and consistency, especially in therapeutic production. However, some applications still favor animal-derived products due to performance.

Q: What is the addressable market for Dyadic's products, and what are the expected royalty rates? A: Joe Hazelton, COO: The addressable market varies by segment. For example, the cell culture media market is $4.7 billion, with a significant portion being recombinant. Royalty rates also vary by product and market, typically ranging from 3% to 10%, or profit-sharing arrangements.

For the complete transcript of the earnings call, please refer to the full earnings call transcript.