中国首款，驻昌平企业创新药完成首例受试者给药

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新京报讯据“北京昌平”微信公众号消息，未来科学城生命谷企业诺诚健华近日宣布，中国首款、全球第二款进入临床的VAV1分子胶降解剂ICP-538完成首例受试者给药。ICP-538是诺诚健华自主研发的新型口服高效、高选择性靶向VAV1的特异性分子胶降解剂，VAV1是T细胞和B细胞受体下游的关键蛋白。ICP-538通过选择性介导CRBN E3泛素连接酶与VAV1蛋白形成三元复合物，剂量依赖性地诱导...

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